Biochemistry Flashcards
Rate limiting step in glycolysis
Phosphofructokinase
Kreb cycle rate limiting enzyme
Isocitrate dehydrogenase
What factor is heamophilia A deficient in
Factor VIII
What factor is heamophilia B deficient in
Factor IX
What factor is heamophilia C deficient in
Factor XI
Which clotting pathway is affected by the heamophilias
Intrinsic pathway
What is Von Willebrand disease deficient in
Von Willebrand factor - autosomal dominant - stabilises factor VIII
What clotting factors does vit K affect
Factors II, VII, IX, X
What factors are in the extrinsic pathway
Factors VII + III
What factors are in the common pathway
X, V, II, I
What clotting factors do vit K affect
Factors II, VII, IX, X
Protein C and S
What enzyme does vit K use as a co-factor
Y-glutamyl carbixylase
What converts inactive Vit K to active Vit K
Epoxide reductase
How does warfarin work
Vit K epoxide reductase
(Vit K cannot be recycled)
