Gut Immunity, Shynra, Russian

Question 1

Dendritic cells stimulate expansion of induced Treg cells by mech dependent on what molecules

Answer 1

TGF-B, IDO, Retinoic acid

Question 2

DCs stimulate IgA secreting plasma cells through what mechs

Answer 2

Ret acid dependent

Question 3

treg cells secrete IL what

Answer 3

10

Question 4

what 3 things supress inflammation?

Answer 4

folate, vit A and D and long chain FA

Question 5

what cause inflammation

Answer 5

high fat diet and medium chain TG

Question 6

____ is full of TGF-B which causes B cells to form IgA

Answer 6

lamina propria

Question 7

antigens are captured in the ___ and ____ and carried to the mesenteric ____ by DCs

Answer 7

lamina propria and peyer’s patches carried to LN

Question 8

mast cells make de novo and release what as the late onset of allergy

Answer 8

cytokines

Question 9

2 things mediate the local acute GI response (diarrhea) to allergen exposure

Answer 9

serotonin and PAF realeased from mast cells

-increases vascular permeability and smooth muscle contractility

Question 10

nut allergy mediated by what

Answer 10

IgE cross linking FcERI

IgG induced activation of macrophages

Question 11

____ released from activated mast cells act on what and generate what

Answer 11

tryptase act on C3 and C5 and create C3a and C5a which activate mast cells to further exacerbate symptoms

Question 12

strong link between celiac disease and what

Answer 12

autoimmunity, 20% or CD patients have or will develop autoimmune diseases

Question 13

gluten is rich in what

Answer 13

proline and glutamine

Question 14

gluten is poorly digested in SI due to lack of ____

Answer 14

prolylendopeptidases

Question 15

majority of CD patients express the what

Answer 15

HLADQ2.5 heterodimer

Question 16

how does tissue damage occur in gluten allergy

Answer 16

type IV hypersensitivity of activated cytoxic T celsl

Question 17

gluten causes T cell mediated inflammatory response in small bowel that damages ___ and leads to
__

Answer 17

mucosa and leads to malabsorption

Question 18

what cross links gluten peptides and TG2 in lamina propria

Answer 18

inflammatory mediators in non healthy individual causes this

Question 19

activated CD4 T cells secrete mainly ___ cytokines such as ___ which induces the release of ___ by ___ resulting in mucosal ___ and villus atrophy

Answer 19

Th1, IFN-y, MMPs, myofibroblasts, remodeling

Question 20

what interluek links adaptive immune system to the innate immune response

Answer 20

IL-15

Question 21

how do you measure for celiac disease

Answer 21

measure total serum IgA if it is too low, also do intestinal biopsy to confirm diagnosis