Guillan-Barre Syndrome Flashcards
What is GBS?
Guillan-Barre Syndrome
Post-infectious demyelination of the PNS
Which infections are associated with GBS?
Campylobacter jejuni
CMV
EBV
What are the features of GBS?
Symmetrical ascending weakness
Reduced reflexes
Peripheral sensation loss
Neuropathic pain
What is the clinical course of GBS?
Infection
4 weeks -> symptoms start
2-4 weeks -> symptoms peak
Months-years -> recovery
What criteria is used to diagnosis GBS?
Brighton criteria
What is the Brighton criteria?
Progressive weakness in both arms and legs Arreflexia/hyporeflexia Progression of symptoms over 4 weeks Relatively symmetrical Mild sensory symptoms Autonomic dysfuntion CN involvement
How can GBS be investigated?
Nerve conduction studies
LP
What does an LP show in GBS?
Raised protein
Normal cells
How is GBS managed?
Supportive care
IV immunoglobulins
Plasma exchange
What are complications of GBS?
Autonomic dysfunction
Respiratory failure
Pain
VTE
What are features of autonomic dysfunction?
Orthostatic hypotension
Sweating abnormalities
Urinary problems
Sexual problems
What condition is associated with GBS?
Miller Fisher syndrome
What is Miller Fisher syndrome?
Variant of Guillain-Barre syndrome
Features
- ophthalmoplegia
- areflexia
- ataxia
- descending paralysis
What antibody is associated with Miller Fisher syndrome?
Anti-GQ1b
