growth hormone

Question 1

GH

Answer 1

metabolism; protein anabolic, glucose-sparing, lipolytic
from hypothalamus;
- GHRF, increases cAMP (Gs) > GH (promote by T3)
- somatostatin; decreased cAMP (Gi) > no GH

IGF-1, growth of tissue, has negative effect on the GH, positive effect on somatostatin

GH has negative effect on hypothalamus/GHRF

Question 2

somatostatin

Answer 2

inhibits the pituitary from producing GH, stimulated by IGF-1

Question 3

octeotride, lanreotide (pasireotide)

Answer 3

somatostatin analogues
inhibiting GH, by inhibiting pituitary
prolonged duration of action compared to somatostatin
used in excessive production of GH

Question 4

somatropin

Answer 4

used in growth hormone deficiency
activator of GH effect

Question 5

mecasermin

Answer 5

used in growth hormone deficiency
stimulates growth of tissue

Question 6

sermorelin

Answer 6

used in growth hormone deficiency
stimulates pituitary

Question 7

pegvisomant

Answer 7

growth hormone receptor antagonist
used in excessive production of GH