Granulopoiesis

Question 1

earliest recognizable granulocyte precursor using light micrscope

Answer 1

Myeloblast

Question 2

synthesis of primary granules begins & ends here

Answer 2

Promyelocyte

Question 3

primary granules are rich in

Answer 3

peroxidase

Question 4

primary granules

Answer 4

azurophilic, nonspecific

Question 5

synthesis of secondary granules

-last stage to undergo mitosis

Answer 5

Myelocyte

Question 6

• nucleus becomes indented
• indention of nucleus must be less than half the width of the nucleus
• synthesis of tertiary granules

Answer 6

Metamyelocyte

Question 7

other name for metamyelocyte

Answer 7

Juvenile cell

Question 8

other name for tertiary granules

Answer 8

gelatinase granules

Question 9

shape of metamyelocyte

Answer 9

kidney bean or peanut shaped

Question 10

• are normally present in small amounts in the peripheral blood
• secretory granules
• counts as neutrophil

Answer 10

Band (Stab Staff Cell)

Question 11

Band is also known as

Answer 11

Immature cell

Question 12

• nonsegmented neutrophil, neutrophil staff or stab

- filaments are not present

Answer 12

Neutrophil

Question 13

nucleus of neutrophil

Answer 13

• 2 to 5 segments connected by threadlike filaments

- elongated, curve or sausage shaped w/ round ends

Question 14

cytoplasm of neutrophil

Answer 14

• pink to tan w/ violet or lilac granules

- identical to the PMN

Question 15

pools in the bone marrow

Answer 15

• stem cell pool
• mitotic pool
• storage pool

Question 16

acronym PMN

Answer 16

polymorphonuclear cells

Question 17

pools in peripheral blood

Answer 17

circulating

marginal

Question 18

pool in PB found in plasma

Answer 18

Circulating

Question 19

pool in PB found adhering to blood vessel wall

Answer 19

Marginal

Question 20

-contain myeloperoxidase acid, defensis etc

Answer 20

Primary or Azurophilic granules

Question 21

increased level of neutrophil

- bacterial infection, leukemia

Answer 21

neutrophilia

Question 22

• decrease level of neutrophil

- nutrient defficiency

Answer 22

Neutropenia

Question 23

extreme neutropenia

-adverse drug effect

Answer 23

Agranulocytosis

Question 24

nucleus of eosinophil

Answer 24

dark, purple, usually band shaped or segmented into only 2 segments

Question 25

2 segments

Answer 25

bilobed

Question 26

cytoplasm of eosinophil

Answer 26

filled w/ large spherical granules of uniform size that stain bright orange

Question 27

major role is for parasitic infection & hypersensitivity raction

Answer 27

Eosinophil

Question 28

outer granules of eosinophil contain:

Answer 28

peroxidase

Question 29

inner granules of eosinophil contain:

Answer 29

basic protein

Question 30

more than 50% protein of eosinophil is made up of

Answer 30

major basic proein

Question 31

play role in the cell’s ability to damage parasitic invaders

Answer 31

Major basic protein

Question 32

• can be found in sputum of asthma patients
• disintegration products of EO
• hexagonal, bipyramidal crystals

Answer 32

Charcot Leyden crystals

Question 33

decrease number of eosinophil

- asthma, scarlet fever & parasitic infection

Answer 33

Eosinophilia

Question 34

decrease number of eosinophil

- side effect of ACTH administration

Answer 34

Eosinopenia

Question 35

nucleus of basophil

Answer 35

difficult to see because of overlying granules

Question 36

cytoplasm of basophil

Answer 36

densely stained, blue black granules

Question 37

some of the contents of basophil granules

Answer 37

• histamine
• Il-4
• IL-13
• Chondroitin Sulfates

Question 38

• immediate hypersensitivity reactions

- hypothyroidism

Answer 38

basophilia

Question 39

• deficiency of basophils
• acute infections
• stress

Answer 39

Basopenia