Granulomatosis with polyangiitis

Question 1

What are the features of granulomatosis with polyangiitis?

Answer 1

Epistaxis
Nasal crusting
Hearing loss
Sinusitis
Saddle shaped nose
Cough
Wheeze
Haemoptysis
Rapidly progressing glomerulonephritis

Question 2

What investigations are used in the diagnosis of granulomatosis with polyangiitis?

Answer 2

cANCA
FBC - normocytic anaemia + thrombocytosis
U&Es
CXR - multiple nodules

Question 3

What is the management of granulomatosis with polyangiitis?

Answer 3

High dose steroids + rituximab
Maintenance - rituximab, azathioprine, methotrexate

Question 4

What is eosinophilic granulomatosis with polyangiitis also called?

Answer 4

Also called Churg-Strauss syndrome

Question 5

What are the features of eosinophilicgranulomatosis with polyangiitis?

Answer 5

Adult onset asthma
Blood eosinophilia
Paranasal sinusitis
Mononeuritis multiplex
Renal involvement
Fever, malaise, myalgia

Question 6

What investigations are used in the diagnosis of eosinophilic granulomatosis with polyangiitis?

Answer 6

Induction - steroids
Maintenance - azathioprine, methotrexate or rituximab