Gram +ve Pathogens Staphylococcus Flashcards
What are the 2 types of Staphylococci?
Staphylococci aureus (S.aureus)
Staphylococci epidermidis (S.epidermis)
What are some S.aureus skin infections?
Rash
Folliculitis
Abscess
Carbuncle
Impetigo
Scalded skin syndrome
What are some facts about S.aureus?
S. aureus
- 20%-(60%) colonisation (carriage)
- main sites nose and perineum
- aquired in healthcare setting (nosocomial) & community
- key virulance factor to aggulate plasma
What is MRSA
A strain of S.aureus
- flucloxacillin resistance
Staphylococcus aureus has many virulence factors such as……
Firbinogen binding protein
adhesin
clots plasma
kills leukocytes
TSST-1 (toxin)
and many more!
each staph wont have all virulence factors
What happens in TSST-1?
• rapid progression (48 hrs) high fever, vomiting, diarrhea, sore throat, muscle pain,
What is toxic shock syndrome?
S.aureus
usually happens with infected tampon, toxin is absorbed through wall of vagina and acts like superantigen.
Fever and hypotension
What is one of the blood clotting factors?
• Fibrinogen -Binding (ClfA ClfB )
What is Panton-Valentine Leukocidin?
• PVL associated with severe skin infections
e. g. - recurrent furunculosis
- sepsis/necrotising fasciitis
PVL & a-toxin linked with CA-MRSA responsible for necrotizing pnuemonia & contagious severe skin infections
What is Necrotizing pneumonia?
Preceding Influenza like syndrome
- Necrotising hemorrhagic pneumonia
- Rapid Progression
- Acute Respiratory distress
- Deterioration in pulmonary function
- Refractory Hypoxamenia
- Multi-organ failure despite Antibiotic therapy
What are some bacterial infections of salivary glands?
(4)
- Acute bacterial parotitis
- Chronic bacterial parotitis
- Recurrent parotitis of childhood
- Submandibular sialadentitis
What is resistant to Flucloxacillin?
Staphylococcus aureus, MRSA is resistant to Flucloxacillin
