Gram Indeterminate Bacteria Flashcards
Important characteristics of Chlamydia
Obligate intracellular
Cannot be gram stained
No muramic acid in cell wall
Can’t synthesise ATP (energy parasites)
Forms of Chlamydia
Elementary body (infective form) Reticulate body (replicative form) (binary fission)
Ags in Chlamydia
LPS
Species specific protein Ag
Serovar specific Ag (MOMP)
Stains for Chlamydia
Giemsa
Castadena
Lugols iodine (for inclusions)
Culture of Chlamydia
Egg yolk
Cell line culture (HeLa, Hep2)
Main method of DX of Chlamydia
NAAT
Types of Chlamydia
C. Tranchomatis
C. Pneumoniae
C. Psittaci
Serotypes of c. Tranchomatis and their diseases
A-C -> Blindness (keratoconjunctivitis)
D-K -> STI
L1-L3 -> lymphogranuloma venereum
Blindness caused by C. Trachomatis
Leading cause of blindness in world
Transmission - hand to eye contact
STI caused by C. Trachomatis
Water discharge
Complications: PID, cervicitis, salpingitis
Can transmit to baby
Neonatal effects of STI caused by C. Trachomatis
Neonatal conjunctivitis (in 1-2 wks) Neonatal pneumonia (stecotto cough)
Lymphogranuloma venereum
C. Tranchomatis
Inguinal l.n
Painless genital ulcers progress to tender painful lymphadenopathy
Reactive arthritis
Reiters syndrome
AI
Sacroiliac and knee
Uveitis, urethritis, arthritis (can’t see, can’t pee, can’t climb a tree)
C. Pneumoniae
Atypical/walking pneumonia Elderly -Pharyngitis -sinusitis -Exacerbate asthma and COPD
C. Psittaci
Pneumonia transmitted from birds
Treatment of Chlamydia
No penicillins
Azithromycin
Doxycycline
Ceftriaxone (for gonorrhea coinfection)
General features of coxiella burnetti
Gram -
Obligate intracellular
Transmission of coxiella burnetti
Spore like structures found in animal feces
Aerosol transmission
Coxiella burnetti C/F
Q fever:
- NO RASH
- HEPATITIS
- Fever
- Pneumonia
- Headache
Self limiting
Gardnerella vaginalis causes
Bacterial vaginosis
Gardnerella vaginalis general features
Gram variable rod
Non motile
Metachromatic granules
