GP Week 5 Flashcards
An approach for testing for coeliac disease: If not eating gluten.
- Gluten challenge
- 2 slices of bread for 2-8 weeks
- Coeliac serology
- If negative at 2 weeks continue and recheck at 8 weeks
An approach for testing for coeliac diaease: If EATING gluten.
- Coeliac serology
a) IgA - tTG
b) IgA - EMA
c) IgA - DGP
Next step if patient returns positive coeliac serology.
- Refer for duodenal biopsy.
Management of coeliac patient at time of diagnosis.
- Refer to dietitian.
- Investigate and treat micro-nutrient deficiencies.
- Review for co-morbidity.
- Review immunisation status.
- Encourage support group engagement.
Management of coeliac patient at 3-6 month review.
- Assess response to diet.
2. Recommend screening of first degree relatives.
What gene is tested for in detection of coeliac disease?
- HLA DQ2/ DQ8
Assessments to be made in dementia.
- Clinical history + collateral
- Physical examination
- Review activities of daily living.
- Geriatric depression scale
- Medication review.
- Cognitive screen/ MMSE
Routine tests for dementia.
- FBC
- ESR
- LFTs
- Calcium
- TFTs
- B12, folate
- CT brain w/o contrast
Other tests (not routine) for consideration in dementia.
- CXR
- BGL
- Lipids
- Homocysteine level
- ECG
- MSU
- HIV serology, syphilis screen
Special investigations for dementia.
- EEG
- MRI
- PET Scan
- Apolipoprotein E (increase = increased risk)
- Neuropsychological assessment
Pain Assessment 4 P’s
- Pain
- Pathologies/ past medical history
- Performance
- Psychological/ psychiatric
Management strategies regarding pains 4 P’s
- Physical
- Psychological
- Pharmacological
- Procedural
Follow up of 6 A’s in regards to pain assessment and management.
- Activities
- Analgesia
- Adverse effects
- Aberrant behaviours
- Affect
- Adequate documentation.
Symptoms of lactose intolerance.
- Abdominal discomfort.
- Bloating.
- Wind.
- Diarrhoea.
Summary of irritable bowel syndrome/ intolerance management,
- Investigate diet and potential intolerance.
- Consider FODMAP’s, caffeine and lactose as co-contributors.
- Consider coeliac serology
- Consider lactose hydrogen breath test.
- Look for red flags: anaemia, bleeding, weight loss.
- Colonoscopy after age 40
First line drug therapies to consider for diabetic polyneuropathy.
- Duloxetine
- Gabapentin
- Pregabalin
- TCA
- Venlafaxine
First line drug therapies to consider for?
- Duloxetine
- Gabapentin
- Pregabalin
- TCA
- Venlafaxine
- Diabetic polyneuropathy.
First line drug therapies to consider for postherpetic neuralgia.
- TCA
- Gabapentin
- Pregabalin
- 5% lignocaine patch
First line drug therapies to consider for?
- TCA
- Gabapentin
- Pregabalin
- 5% lignocaine patch
- Postherpetic neuralgia.
First line drug therapies to consider for trigeminal neuralgia.
- Carbamazepine.
2. Oxycarbazepine.
First line drug therapies to consider for?
- Carbamazepine.
- Oxycarbazepine.
- Trigeminal neuralgia.
Drug therapies to consider for chronic regional pain syndrome.
- Oral prednisone.
- Bisphosphonates.
- Gabapentin.
- Opioids.
- NSAIDs
- Topical capsaicin.
- IV lignocaine.
Drug therapies to consider for?
- Oral prednisone.
- Bisphosphonates.
- Gabapentin.
- Opioids.
- NSAIDs
- Topical capsaicin.
- IV lignocaine.
- Chronic regional pain syndrome.
Diagnostic indications for PPI use.
- GORD
- Functional dyspepsia
- Barrett’s oesophagus
- Peptic ulcer disease (H.pylori)
- Peptic ulcer disease (NSAID)
Potential harms associated with long term PPI use.
- Bone fractures
- Pneumonia
- Enteric infections
- Vitamin and mineral deficiencies
- Acute interstitial nephritis
Current PPIs for GP prescription.
- Esomeprazole
- Lansoprazole
- Omeprazole
- Pantoprazole
- Rabeprazole
- Esomeprazole
- Lansoprazole
- Omeprazole
- Pantoprazole
- Rabeprazole
- Current PPIs for GP prescription.
Red flag symptoms in GORD patient requiring urgent endoscopy.
- Dysphagia.
- Odynophagia.
- Unexplained weight loss
- Persistent vomiting.
- Haematemesis or Melaena.
- Signs of anaemia.
Lifestyle interventions for patients with GORD.
- Avoid foods or drinks that trigger symptoms.
- Avoid late or large meals, and lying down immediately following meal.
- Raise the head of the bed.
- Lose weight.
- Reduce alcohol intake.
- Smoking cessation.
Questions to ponder in the pre-treatment evaluation of Hepatitis C Virus infection.
- HCV genotype? (1-6)
- Evidence of cirrhosis?
- Is the patient treatment naive or treatment experienced?
- Is there any priority co-morbidity?
- Medication interactions?
- Is a specialist referral required?
Direct acting antiviral (DAA) treatment for HCV: Genotype 1
- Ledipasvir
plus - Sofosbuvir
Direct acting antiviral (DAA) treatment for HCV: Genotype 2
- Sofosbuvir
pluse - Ribavirin
Direct acting antiviral (DAA) treatment for HCV: Genotype 3
- Daclatasvir
plus - Sofosbuvir
Direct acting antiviral (DAA) treatment for HCV: Genotype 4-6.
1. Sofosbuvir plus 2. PEG-IFN (peginterferon alpha 2a) plus 3. Ribavirin
The following drugs are used for?
- Sofosbuvir
- Ledipasvir
- Ribavirin
- Daclatasvir
- PEG-IFN (peginterferon alpha 2a)
- Direct acting antivirals (DAA) for Hepatitis C.
Likely diagnosis for anorectal pain: Pain alone.
- Anal fissure.
- Anal herpes.
- Ulcerative proctitis.
- Proctalgia fugax.
Likely diagnosis of anorectal pain: Pain and bleeding.
- Anal fissure.
2. Proctitis.
Likely diagnosis of anorectal pain: Pain, lump, and bleeding.
- Second degree haemorrhoid. (lump spontaneously reduces)
- Third degree haemorrhoid. (Lump prolapse but reducible)
- Fourth degree haemorrhoid.
- Ulcerated perianal haematoma (blood on underwear)
Likely diagnosis of anorectal complaint: Lump alone (no pain)
- Skin tag.
- Perianal wart
- Anal carcinoma.
Likely diagnosis of anorectal complaint: Lump with bleeding (no pain)
- Second degree haemorrhoid.
2. Anal carcinoma.
Likely diagnosis of anorectal complaint: Bleeding alone (no pain, no lump)
- Internal haemorrhoids (blood on and separate to faeces)
- Colorectal polyps (blood mixed with faeces)
- Colorectal carcinoma (blood mixed with faeces)
- Anal carcinoma
Likely diagnosis of anorectal pain: Pain with Lump
- Perianal haematoma
- Strangulated internal haemorrhoid
- Abscess
- Pilonidal sinus
Step-wise haemorrhoid treatment.
- High fibre diet.
- Sclerosant injection
- Rubber band ligation.
- Referral for surgical haemorrhoidectomy.
Step-wise anal fissure treatment.
- Avoid constipation: high fibre diet
- Topical anaesthesia
- Topical GTN
- Botulinim toxin.
- Referral for subcutaneous sphincterotomy