GP Week 1 Flashcards
Exam Prep
Presenting symptoms of breast cancer?
- New breast lump (most common)
- Thickening or ridge
- Breast or nipple asymmetry
- Skin changes (dimpling, redness)
- Nipple changes
- Nipple discharge
- Unilateral breast pain
The triple test refers to what three diagnostic components?
- Medical history and breast examination.
- Imaging; mammography and/ or ultrasound
- Non-excisional biopsy; core biopsy and/ or fine needle aspiration cytology
Risk factors of endometrial cancer.
- History of chronic anovulation.
- Exposure to unopposed oestrogen.
- PCOS
- Exposure to tamoxifen.
- Family Hx Lynch syndrome
- Nulliparity
- Obesity
Investigations for abnormal PV bleeding.
- Pelvic examination
- Bloods, and hormones
- Transvaginal ultrasound
- Endometrial biopsy
- Diagnostic hysteroscopy
- D&C
Treatment options for erectile dysfunction.
1st Line:
Alter modifiable risks and causes.
Facilitate sexual health.
2nd Line:
Oral PDE5 inhibitors.
Counselling and education.
Vacuum devices/ rings.
3rd Line:
Itracavernous vasoactive drug injection.
4th Line:
Surgical treatment ? implant.
Oral PDE5 Inhibitors for erectile dysfunction.
- Tadalafil (Cialis)
- Vardenafil (Levitra)
- Sildenafil (Viagra)
Types of lower urinary tract symptoms in men.
- Voiding (obstructive symptoms)
- Storage symptoms
- Complex symptoms.
Voiding or obstructive LUT symptoms in men.
- Hesitancy
- Poor stream.
- Intermittent flow.
- Incomplete emptying.
- Post-void dribbling.
- Overflow incontinence.
Storage LUT symptoms in men.
- Frequency.
- Nocturia.
- Urgency.
- Urgency incontinence.
Complex LUT symptoms in men.
- Haematuria.
- Recurrent UTI
- Acute or chronic urinary retention.
- Urinary incontinence.
Common causes of Storage LUT symptoms in men.
- UTI
- Bladder calculi
- Urothelial carcinoma
- Overactive bladder
Common causes of Voiding (obstructive) LUT symptoms in men.
- Benign prostatic enlargement
- Bladder neck stenosis
- Urethral stricture
- Poor detrusor contractility
Management options of LUTS in older men.
- Watchful waiting.
- Medical management.
- Surgical management.
Medical pharmoacotherapy for LUTS in men.
- Alpha blockers
- Antimuscarinics
- 5 alpha reductase inhibitors
- Combination therapy.
Role of alpha blockers to treat LUTS in men.
- Used to treat voiding/ obstructive symptoms.
2. Block alpha 1A adrenoreceptors to promote prostatic smooth muscle and bladder neck relaxation.
Role of antimuscarinics to treat LUTS in men.
- Used to treat storage symptoms.
2. Inhibits acetylcholines effect on muscarinic M3 receptors and hence reducing detrusor muscle contractions.
Role of 5 alpha reductase inhibitors to treat LUTS in men.
- Use to treat obstructive symptoms.
- They inhibit the enzyme 5 alpha reductase to block the conversion of testosterone into the more potent DHT form.
- This induces prostatic cell apoptosis and thus reduces prostate size.
Surgical treatments for LUTS.
- Ablative - needle ablation, or microwave therapy
2. Cavitating - TURP or laser
Symptoms of prostatitis.
- Dysuria
- Urgent need to urinate.
- Frequent urinating.
- Painful ejaculation.
- Pain, lower back and perineum
- Chills/ fevers
- Muscular pain
- General lack of energy
Investigation in prostatitis.
- DRE
- PSA
- Urinalysis, 1st pass for chlamydia and midstream for M/C/S