GORD

Question 1

antacids

Answer 1

Magnesium trisilicate
Aluminium/magnesium mixtures (Maalo)
Alginate

Question 2

how does Magnesium trisilicate aid healing of ulcers

Answer 2

deliver growth factors to injured mucosa
promote angiogenesis in injured mucosa
bind bile acids and also inhibit peptic activity.

Question 3

what do heavy metals like Magnesium trisilicate do to H pylori

Answer 3

Heavy metals suppress, but generally do not eradicate, H. pylori

Question 4

Aluminium/magnesium mixtures work as

Answer 4

antacids

Question 5

how does increasing the pH help with ulcers

Answer 5

inhibits pepsin

Question 6

antacid that forms a foam raft

Answer 6

Alginates

Question 7

what happens to the raft

Answer 7

becomes foam when carbon dioxide gets trapped

Question 8

ranitidine class

Answer 8

Histamine H2 receptor antagonists

Question 9

ranitidine target

Answer 9

Histamine H2 receptor in gastric parietal cell

Question 10

ranitidine action

Answer 10

Competitive antagonist

Question 11

ranitidine indications

Answer 11

GORD; Peptic Ulcer Disease; Dyspepsia

Question 12

ranitidine bad side effects

Answer 12

Gynaecomastia, impotence

Question 13

which H2 antagonist causes impotence

Answer 13

cimetidine

Question 14

ranitidine cautions

Answer 14

hepatic or renal impairment

Question 15

ranitidine might mask

Answer 15

cancer

Question 16

why avoid use of cimetidine inpatients on warfarin, theophylline and phenytoin

Answer 16

cytochrome P450 inhibitor

Question 17

what cells do PPIs work on

Answer 17

parietal cell

Question 18

what does the PPI target

Answer 18

H+/K+-ATPase

Question 19

transport of which ion is stopped in PPI use

Answer 19

H into the stomach lumen