goodpastures syndrome Flashcards
1
Q
what is goodpastures syndrome
A
type 2 autoimmune hypersensitivity response resulting in pulmonary and renal pathology.
2
Q
what is the tell tale sign of goodpastures in exam
A
HAEMOPTYSIS + HAEMATURIA SIMULTANEOUSLY
3
Q
pathophysiology of goodpastures
A
ANTI-GBM antibodies attack basement membranes of alveoli and glomeruli
→ alveolar haemorrhage and nephritic syndrome
4
Q
lung symptoms of good pastures
A
cough, haemoptysis, chest pain
5
Q
renal symptoms of good pastures
A
haematuria, htn, oedema
6
Q
2 investigations for good pastures
A
- serology
- lung and kidney biopsy
7
Q
what does goodpastures serology show
A
anti GBM +ve
8
Q
what does lung and kidney biopsy for goodpastures show
A
Ig complex formation, general damage
9
Q
how to treat goodpastures
A
corticosteroids (prednisolone) + plasma exchange
