Gonadogenesis

Question 1

What occurs when small numbers of primordial germ cells reach genital ridge?

Answer 1

Results in small testis/ovaries

Question 2

Two main mechanisms that will determine sex?

Answer 2

Genetic sex determination

External sex determination

Question 3

What are 2 sex determing genes?

Answer 3

Sry (mammalian)

dmrt1 (chicken)

Question 4

Where is the sry sex determining gene located?

Answer 4

Y chromosome

Question 5

What cells express Sox 9

Answer 5

Sertoli cells

Question 6

What does Sox9 stimulate?

Answer 6

Production of AMH

Question 7

What is B-Catenin?

Answer 7

Stimualted by negative regulators

Degrades Sox9

Question 8

What do negative regulators do?

Answer 8

Inhibit Sox9

Stimulate B-Catenin

Inhibit Ptgds

Question 9

What occurs when ram has a mutation in the Sry?

Answer 9

You will have down regulation of Sox9 and therefore you will not have Amh, therefore you will have a male with female phenotype

Question 10

What does Amh stand for?

Answer 10

Anti-mullerian hormone

Question 11

How does Amh cause for differentiation of male phenotyp?

Answer 11

Causes for regression of paramesonephric ducts

Question 12

What do leydig cells produce?

Answer 12

Androgen

Question 13

What will the number of germ cells at birth determine?

Answer 13

Reproductive life of an animal

Question 14

What occurs to 1% of germ cell population?

Answer 14

Reach the preovulatory stages