Generating an Egg Flashcards
What 9 things does the follicular fluid of the antral follicle contain?
Proteins Amino Acids Enzymes Carbohydrates Glycoproteins Gonadotropins Steroids Prostaglandins Elements/Salts
What is in high concentration in the graafian follicle
Estrogen
When are follicles gonadotrophin dependent and independent?
Independent = Preantral Dependent = Antral
How is estrogen produced by the follicle?
The theca interna cell is activated by LH which causes for Cholesterol to be converted into Testosterone
Testosterone passes to the Granulosal Cell
Granulosal Cell is activated by FSH which causes for testosterone to be converted to Estradiol which is released into the blood
Explain very simply the steps in towards becoming an ovulatory follicle
Recruitment: A number of ovarian follicles are recruited and produce estrogen.
Selection: From the recruitment group a few follicles continue to grow while the rest undergo atresia. These follicles become antral follicles. A larger amount of estrogen is produced than from the recruitment group
Dominance: An even fewer number of follicles continue to grow and the rest undergo atresia. From here some will ovulate while the others will undergo atresia.
All of these steps are controlled by genes and hormones
How is the diplotene stage maintained?
High levels of cAMP maintain a nuclear arrest
What produces the cAMP?
Cumulous cells
How are cumulus cells and oocyte connected?
Connected via gap junctions which allows for the transfer of cAMP and other materials such as glucose
What is responsible for the resuming of meiosis after diplotene stage?
Surge of LH
