Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BIOCHEMISTRY > GLYCOPROTEINS > Flashcards

GLYCOPROTEINS Flashcards

1
Q

A protein covalently linked to carbohydrates

A

glycoprotein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What types of glycosidic bonds are found in glycoproteins?

A

N-glycosidic, O-glycosidic, and glycosylphosphatidylinositol-anchored (glypiation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Function of glycans in glycoproteins?

A

Cell signaling, recognition, stability, and folding.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Process of N-glycosylation?

A

Attachment of GlcNAc-PI to Asn residues.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Process of O-glycosylation?

A

Attachment of GalNAc to Ser/Thr residues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Impaired glycoprotein function due to defective glycosylation.

A

Congenital Disorders of Glycosylation (CDG)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is glypiation?

A

Attachment of GPI anchor to C-terminal amino acids.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How does altered glycosylation contribute to cancer?

A

Changes in cell-cell interactions and receptor-ligand binding.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Role of glycoproteins in immunodeficiency?

A

Impaired immune response due to defective glycoprotein function.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Enzymes catalyzing glycosidic bond formation

A

glycosyltransferases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Enzymes catalyzing glycosidic bond hydrolysis.

A

glycosidases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Proteins binding specific glycans

A

lectins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the role of glycoproteins in protein stability?

A

Maintaining protein conformation and preventing degradation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the role of glycoproteins in immune response?

A

Activating immune cells and mediating inflammation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the role of glycoproteins in cell signaling?

A

Mediating cell-cell interactions and receptor-ligand binding.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

enzyme responsible for N-glycosylation?

A

Oligosaccharyltransferase.

13
Q

Enzymatic attachment of sugars to proteins

A

glycosylation

14
Q

Nonenzymatic attachment of sugars to proteins

A

glycation

15
Q

This process can have serious pathologic consequences

A

glycation

16
Q

Often found in glycoproteins, attached to galactose, N-acetylglucosamine, or N-acetylgalactosamine

A

Sulfate

17
Q

Can be used to purify glycoproteins

A

Lectins

17
Q

Plant lectins were formerly called

A

Phytohemagglutinins

18
Q

Common sugar in N-linked glycoproteins

A

Mannose

19
Q

Present in both N-and O-linked glycoproteins

A

N-Acetylgalactosamine

20
Q

An important red cell membrane glycoprotein that contains both O-and N-linked oligosaccharides

A

Glycophorin

21
Q

Four subclasses of O-glycosidic linkages

A

N-acetylgalactosamine-Ser(Thr)
Proteoglycans
Collagen
Nuclear and cystolic proteins

22
Q

The predominant linkage that found in mucins

A

N-acetylgalactosamine-Ser(Thr)

23
Q

Contain a galactose-galactose-xylose trisaccharide attached to serine

A

Proteoglycans

24
Q

Side chains consisting of single N-acetylglucosamine attached to serine or threonine residue

A

Nuclear and cystolic proteins

24
Q

Contain galactose-hydroxy-lysine linkage

A

Collagen

25
Q

Have a high content of O-linked Oligosaccharides

A

Mucins

26
Q

Oligosaccharide branches are often referred as

A

Antennae

27
Q

Biosynthesis of N-linked Glycoproteins involves

A

Dolichol-P-P-Oligosaccharides

28
Q

These ensure correct folding of proteins in the endoplasmic reticulum

A

Glycoproteins & Calnexin

29
Q

A chaperone protein in the ER membrane

A

Calnexin

30
Q

Soluble ER protein that performs similar function to that calnexin

A

Calreticulin

31
Q

3 Functions of GPI

A

Mobility
Signal transduction
target proteins

32
Q

The overall series of reactions which involve in the browning of certain foodstuffs during storage or heating

A

Maillard reaction

32
Q

Important in causing tissue damage in diabetes mellitus

A

Advanced glycation End-Products (AGEs)

BIOCHEMISTRY (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions