GLYCOLYSIS Flashcards
represents an ancient process by all cells of the human body, in which anaerobic degradation of glucose to lactate occurs with release of energy as ATP
Embden-Meyerhof or the Glycolytic Pathway
-2 ATPs are needed to convert Glucose to Fructose 1,6-Bisphosphate. -ATP in this stage is “invested” rather than utilized
PRIMING STAGE
- Fructose 1,6-Bisphosphate is “split” into 2 molecules of Glyceraldehyde 3- Phosphate
SPLITTING STAGE
- 2 molecules of Glyceraldehyde 3- Phosphate are converted into 2 molecules of lactate with the 4 molecules of ATP
OXIDOREDUCTION-PHOSPHORYLATION STAGE
converts Glucose to G6P
HEXOKINASE
transforms the G6P to F6P
PHOSPHOGLUCOSE ISOMERASE
adds an additional Phosphate Group to F6P to make it Fructose 1,6- Biphosphate
PHOSPHOFRUCTO KINASE
several effectors and is often considered as the key regulatory enzyme in glycolysis
PHOSPHOFRUCTO KINASE
cleaves FBP to Dihydroxyacetone phosphate and Glyceraldehyde-3- Phosphate
ALDOLASE
catalyzes reversible interconversion of DHAP and GAP
TRIOSE PHOSPHATE ISOMERASE
_ mol of Glucose in converted to _ mol of GAP
1 mol of Glucose
2 mol of GAP
oxidizes an ALDEHYDE to CARBOXYLIC ACID with the reduction of NAD to NADH
GLYCERALDEHYDE 3- PHOSPHATE DEHYDROGENASE
produces ATP from a high energy molecule of 1,3-Bisphosphate
*first site of ATP production in Glycolysis
PHOSPHOGLYCERATE KINASE
catalyzes the reversible reaction wherein 3-phosphoglycerate is converted to 2- phosphoglycerate w/c is an obligatory intermediate at the active site
PHOSPHOGLYCERATE MUTASE
eliminates water from 2-PG to form phosphoenolpyruvate
ENOLASE
