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6to > Glucocorticoides Y Mineralocorticoides > Flashcards

Glucocorticoides Y Mineralocorticoides Flashcards

1
Q

Zona de produccion de mineralocorticoides

A

Zona glomerulosa

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2
Q

Cortisol y corticoesteroma

A

Glucocorticoides

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3
Q

Aldosterona y desoxicorticoesterona

A

Mineralocorticoides

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4
Q

Precusor de corticoides

A

Colesterol

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5
Q

Colesterol en ldl

A

Esterificado

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6
Q

Funcion de corticotropina

A

Incrementa captacion de ldl e incrementa biodisponibilidad de colesterol

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7
Q

Maxima secrecion de cortisol

A

8 am

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8
Q

Tipo de secrecion de cortisol

A

Pulsatil

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9
Q

Cual es el unico glucocorticoide en sal por via oral

A

Deflazacort

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10
Q

Mecanismo de accion de glucocorticoides

A

Interaccion con GR o MR

Mayor afinidad por tipo I

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11
Q

Ubicacion de GR

A

Diseminado por todo el cuerpo

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12
Q

Sitios de mayor distribucion de MR

A

Riñon, colon, glandulas salivales

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13
Q

Efectos de ausencia de hormonas corticales

A 
Deplecion de glucogeni
Disminuye glicemia
Aumenta eliminacion de sodio en orina
Se reduce nitrogeno no proteico en orina
Disminuye PA
Aumenta concentracion de potasio
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14
Q

Efecto de corticoides en exceso

A

Inhiben reaccion inflamatoria

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15
Q

Efectos metabolicos de glucocorticoides

A

Necesario para gluconeogenesis
Inhibe captacion de glucosa por celulas musculares
Estimula lipolisis

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16
Q

Efectos catabolicos de la piel

A

Disminucion de masa osea, muscular
Adelgazamiento de la piel
Disminucion de crecimiento en niños por supresion de hormona de crecimiento

17
Q

Efectos anti inflamatorios e inmunosupresores

A 
Efecto directo sobre leucocitos
Efecto maximo en 6 horas
Inhiben tnf a
Reducen excrecion de cox 2
Disminuyen sintesis de prostaglandinas leucotrienos y factor activador de plaquetas
No hay produccion de cox 2
18
Q

Mejor actividad topica en efecto corta a intermedia

A

Metil prednisolona

19
Q

Molecula sintetica mas similar al cortisol

A

Hidrocortisona

20
Q

Zona de sintesis de glucocorticoides

A

Zona fasciculada

6to (9 decks)

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