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Renal > Glomerulonephritis > Flashcards

Glomerulonephritis Flashcards

1
Q

Describe glomerular disease

A
  • immune mediated attacking the kidneys glomeruli
  • T cell mediated
  • humoral antibody
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2
Q

Damage to the podocytes results in?

A
  • protein in urine
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3
Q

Damage to the mesagnial cells results in

A
  • blood

- protein

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4
Q

Damage to the endothelial cells results in___ in urine

A
  • blood
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5
Q

Explain a proliferative lesion

A
  • damage to the endothelial or mesangial cells
  • blood in urine
  • rapid decline in renal function
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6
Q

Explain a non-proliferative lesion

A
  • damage to podocytes

- protein in urine

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7
Q

Investigations for a suspected glomerulonephritis?

A
  • urinalysis
  • blood sample
  • renal biopsy
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8
Q

Explain nephritic syndrome

A
  • acute renal failure
  • rapid progression
  • red cell - active urine sediment
  • proliferative
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9
Q

Explain nephrotic syndrome

A
  • non-proliferative
  • oedema
  • proteinuria
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10
Q

Which glomerulonephritis is commonest in children?

A
  • minimal change
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11
Q

Causes of minimal change disease

A
  • Hodgkins lymphoma
  • viral
  • infection
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12
Q

Explain on electron microscopy what would be observed in minimal change?

A
  • damage to podocyte
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13
Q

Which is the commonest glomerulonephritis in adults

A
  • focal segmental glomerulosclerosis
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14
Q

Causes of FSGS

A
  • heroin
  • obesity
  • reflux
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15
Q

On biopsy of FSGS

A
  • Scarring

- mesangial collapse and sclerosis

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16
Q

Minimal change is nephrotic or nephritic?

A
  • nephrotic
17
Q

FSGS is nephrotic or nephritic?

A
  • nephrotic
18
Q

Membranous nephrotic is nephritic or nephritic?

A
  • Nephrotic
19
Q

What antibody is associated with membranous nephropathy?

A
  • aNTI pla2R
20
Q

Causes of membranous nephropathy

A
  • SLE
  • infection
  • Malignancy
21
Q

Thickening of GBM on biopsy?

A
  • membranous nephropathy
22
Q

Mesagnium proliferation on biopsy?

A
  • membranoproliferative

- C3 deposition

23
Q

Which is the commonest glomerulonephritis in the world?

A
  • IgA
24
Q

Antibody associated with IgA glomerulonephritis?

A
  • anti-IgA1
25
Q

Treatment of IgA nephropathy

A
  • blood pressure

- ACEi or ARB

26
Q

What is seen on biopsy of rapidly progressive GN

A
  • Crescent formation

- active urinary sediment

27
Q

Rapidly progressive GN is associated with?

A
  • ANCA and Non-ANCA
28
Q

Treatment of rapidly progressive GN

A
  • immunosuppression
29
Q

Goodpastures syndrome is what antibody?

A
  • anti-GBM
30
Q

Pulmonary renal syndrome is seen in what?

A
  • Goodpastures syndrome
31
Q

IgA nephropathy is nephrotic or nephritic?

A
  • nephritic
32
Q

HSP is nephritic or nephrotic?

A
  • Nephritic
33
Q

Goodpastures is nephritic or nephrotic?

A
  • nephritic

Renal (14 decks)

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