Glomerulonephritis Flashcards
Describe glomerular disease
- immune mediated attacking the kidneys glomeruli
- T cell mediated
- humoral antibody
Damage to the podocytes results in?
- protein in urine
Damage to the mesagnial cells results in
- blood
- protein
Damage to the endothelial cells results in___ in urine
- blood
Explain a proliferative lesion
- damage to the endothelial or mesangial cells
- blood in urine
- rapid decline in renal function
Explain a non-proliferative lesion
- damage to podocytes
- protein in urine
Investigations for a suspected glomerulonephritis?
- urinalysis
- blood sample
- renal biopsy
Explain nephritic syndrome
- acute renal failure
- rapid progression
- red cell - active urine sediment
- proliferative
Explain nephrotic syndrome
- non-proliferative
- oedema
- proteinuria
Which glomerulonephritis is commonest in children?
- minimal change
Causes of minimal change disease
- Hodgkins lymphoma
- viral
- infection
Explain on electron microscopy what would be observed in minimal change?
- damage to podocyte
Which is the commonest glomerulonephritis in adults
- focal segmental glomerulosclerosis
Causes of FSGS
- heroin
- obesity
- reflux
On biopsy of FSGS
- Scarring
- mesangial collapse and sclerosis
Minimal change is nephrotic or nephritic?
- nephrotic
FSGS is nephrotic or nephritic?
- nephrotic
Membranous nephrotic is nephritic or nephritic?
- Nephrotic
What antibody is associated with membranous nephropathy?
- aNTI pla2R
Causes of membranous nephropathy
- SLE
- infection
- Malignancy
Thickening of GBM on biopsy?
- membranous nephropathy
Mesagnium proliferation on biopsy?
- membranoproliferative
- C3 deposition
Which is the commonest glomerulonephritis in the world?
- IgA
Antibody associated with IgA glomerulonephritis?
- anti-IgA1
