GIT Pharmacology

Question 1

Give an overview of the groups of drugs used in the management of peptic ulcers

Answer 1

1. Agents that reduce gastric acidity:
   - Proton pump inhibitors
   - H2 receptor antagonist
   - Muscarinic receptor antagonist
   - Antacids
2. Mucosal protective agents
   - Sucralfate
   - PGE1 agonists
   - Colloidal bismuth compounds (Bismuth Subsalicylates)
   - Carbenoxolone

Question 2

List the proton pump inhibitors

Answer 2

• Omeprazole
• Esomeprazole
• Lansoprazole
• Rabeprazole
• Pantoprazole

Question 3

List the H2 receptor antagonists

Answer 3

• Ranitidine
• Famotidine
• Nizatidine

Question 4

Muscarinic receptor antagonists used for peptic ulcer

Answer 4

• Pirenzepine
• Telenzepine

Question 5

Antacids used in peptic ulcers

Answer 5

• Sodium bicarbonate
• Calcium carbonate
• AI hydroxide
• Magnesium hydroxide

Question 6

What is sucralfate made up of

Answer 6

• Complex aluminum hydroxide + sulfate + sucrose

Question 7

Name of the synthetic analog of prostaglandin E1

Answer 7

Misoprostol

Question 8

List the group of drugs used as antiemetics

Answer 8

• Serotonin 5HT3 antagonists
• Dopamine D2 antagonist
• Anticholinergics
• H1 antihistaminics
• Cannabinoids (Opioid reception antagonist)

Question 9

Examples of serotonin receptor antagonists used as antiemetic

Answer 9

• Ondansetron
• Granisetron
• Dolasetron

Question 10

Dopamine D2 antagonists used as antiemetics

Answer 10

• Metoclopramide
• Domperidone

Question 11

H1 antihistaminics used as antiemetics

Answer 11

• Meclizine
• Cyclizine
• Dimenhydrinate
• Diphenydramine
• Promethazine (used in pregnancy)

Question 12

Anticholinergics used as antiemetics

Answer 12

Scopolamine (Hyosine)

Question 13

Cannabinoids used as antiemetic

Answer 13

• Dronabinol
• Nabilone