GIT Pathogens - Viruses

Question 1

Types of enteropathogenic viruses
1)
2)
3)

Answer 1

1) Rotavirus
2) Norovirus
3) Adenovirus

Question 2

Treatment for viral GIT infections

Answer 2

No specific treatment, as no specific symptoms.

Rehydration therapy.

Question 3

Rotavirus infective dose

Answer 3

10 virions

Question 4

Norovirus infective dose

Answer 4

18 virions (median)

Question 5

Rotavirus genome

Answer 5

dsRNA, segmented genome

Question 6

Norovirus genome

Answer 6

+ sense ssRNA

Question 7

Adenovirus genome

Answer 7

dsDNA

Question 8

Rotavirus, norovirus, adenovirus coats

Answer 8

None

Question 9

Rotavirus capsid

Answer 9

Icosahedral, double capsid

Question 10

Norovirus capsid

Answer 10

T=3 icosahedral capsid

Question 11

Adenovirus capsid

Answer 11

Icosahedral

Question 12

Rotavirus incubation period

Answer 12

2 days

Question 13

Norovirus incubation period

Answer 13

1-2 days

Question 14

Adenovirus incubation period

Answer 14

3-10 days

Question 15

Rotavirus shedding

Answer 15

Up to 10^12 virions/mL of stool

Question 16

Norovirus shedding

Answer 16

Uncommon asymptomatic shedding.

Shedding occurs for 2-3 weeks after symptoms.

Question 17

Rotavirus pathogenesis:
1)
2)

Answer 17

1) Internal trypsin cleaves off outer protein spikes (VP4). This enhances penetration. Method of penetration not known..
2) RNA-dependent RNA polymerase part of genome.