GIT Pathogens - Viruses Flashcards

1
Q

Types of enteropathogenic viruses
1)
2)
3)

A

1) Rotavirus
2) Norovirus
3) Adenovirus

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2
Q

Treatment for viral GIT infections

A

No specific treatment, as no specific symptoms.

Rehydration therapy.

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3
Q

Rotavirus infective dose

A

10 virions

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4
Q

Norovirus infective dose

A

18 virions (median)

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5
Q

Rotavirus genome

A

dsRNA, segmented genome

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6
Q

Norovirus genome

A

+ sense ssRNA

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7
Q

Adenovirus genome

A

dsDNA

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8
Q

Rotavirus, norovirus, adenovirus coats

A

None

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9
Q

Rotavirus capsid

A

Icosahedral, double capsid

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10
Q

Norovirus capsid

A

T=3 icosahedral capsid

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11
Q

Adenovirus capsid

A

Icosahedral

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12
Q

Rotavirus incubation period

A

2 days

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13
Q

Norovirus incubation period

A

1-2 days

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14
Q

Adenovirus incubation period

A

3-10 days

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15
Q

Rotavirus shedding

A

Up to 10^12 virions/mL of stool

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16
Q

Norovirus shedding

A

Uncommon asymptomatic shedding.

Shedding occurs for 2-3 weeks after symptoms.

17
Q

Rotavirus pathogenesis:
1)
2)

A

1) Internal trypsin cleaves off outer protein spikes (VP4). This enhances penetration. Method of penetration not known..
2) RNA-dependent RNA polymerase part of genome.