GIT Flashcards
Layers
Mucosa (simple columnar epithelium)
Sub mucosa (CT)
Muscularis (smooth muscle)
Enteric plexus (nerves)
Serosa/ peritoneum (epithelium)
4 cells in mucosa of stomach
Parietal»_space; HCl +intrinsic factor for B12 absorption
Chief» pepsinogen, peptic
Mucous» alkaline protective mucus
G cells» gastrin- somatostatin -histamine-serotonin
Hcl and i trinsic factor
Parietal/ oxyntic
Food enter lumen (first step)
CO2 enter parietal cell
Combines with H2O in presence of carbonic anhydrase enzyme forming
Carbonic acid
Which dissociates into
Bicarbonate ion and proton
Second step of HCl secretion
Proton pumped out into lumen and bicarbonate pumped out into interstitial space by bicarbonate chloride anti portal
Cl- gets into parietal cell and gets out by chloride channel meeting the proton in the lumen
Combines and forms HCl
Activation of pepsinogen
Chief cells secrete pepsinogen which is inactive
When it meets HCl in lumen it becomes pepsin that digests proteins
Proteins digested into…
Protease
Peptones
HCl is only present when ..
Food is in lumen
T/f HCl is formed inside parietal cells
False outside in lumen to prevent damage
Gastric juice pH and components
1-3.5
Salts /enzymes/HCl/ mucus/ H2O
Inflammation in stomach lining
Gastritis
Symptoms of gastritis
Heartburn
Upper abdominal pain
Nausea
Gastritis causes
Infection with helicobacter pylori, an acid loving bacteria in stomach
Non steroidal anti inflammatory drugs
Auto immune
Radiation
NSAIDs
Non steroidal anti inflammatory drugs
Acute gastritis signs
Mucosal and sub mucosal lymphocytes infiltrated with pockets of polymorph nuclear cells (neutrophils)
Edema water + vaculated epithelium+ lymphocytes
Mild mucosal defects
Inflammation types and differences
Acute» short term/ immense pain treated/healing after
Chronic»long term/active inflammation damage and healing within