GI Pharm Flashcards
Cimetidine
Histamine (H2) antagonist on gastric parietal cells
Ranitidine
Histamine (H2) antagonist on gastric parietal cells
Omeprazole
Gastric proton pump inhibitor. Inhibits H+/K+ ATPase on gastric parietal cells
Pirenzipine (ADD MORE)
M1 antagonist
Bismuth Salicylate
Peptobismol. Good for H. Pylori. Creates a clay that covers ulcers. Good anti-diarrheal
Loperamide
Mu-opiod AGONIST on enteric neurons. Opioid activation decreases Ach release
Diphenoxylate
Mu-opiod AGONIST on enteric neurons. Opioid activation decreases Ach release
Clonidine
Alpha-2 AGONIST on enterics. Alpha 2 agonism decreases Ach release
Alosetron
5HT3 ANTAGONIST. Serotonin receptors promote peristalsis
Octreotide
Somatostatin mimetic. Acts to decreases other gastric secretions. Slows down motility in high doses
Bethanechol
M3 agonist. Promotes gut motility
Neostigmine
Ach esterase inhibitor. Inhibits the enzyme that breaks down Ach and increases Ach presence
Metochlopramide
D2 ANTAGONIST (with 5HT4 agonism functions). Dopamine limits Ach function, so by inhibiting it, you increase Ach activity. Also inhibits D2 on CTZ - functions as anti-emesis
Domperidone
D2 ANTAGONIST. Dopamine limits Ach function, so by inhibiting it, you increase Ach activity.
Prucalopride
5HT4 agonist. Promotes gut motility
Odansetron
5HT3 ANTAGONIST. Anti-emetic (especially for chemo induced vomiting which tends to activate serotonin)
Chlorpromazine
D2 antagonist on emetic pathway. Anti-emetic.
Scopolamine
Muscarinic antagonist. Transdermal patch near the ear. Good for motion sickness
Promethazine
H1 antagonist in the histamine receptor on cerebellum. Sends its neurons to vomiting center. Anti-emetic
D9-THC
Cannabinoid agonist. Prevents NT release on neurons traveling to vomiting center
Aprepitant
NK1 antagonist. Blocks NK1 receptor on chemoreceptor trigger zone (CTZ) and solitary nucleus on the path to vomiting center
Ipecac
Pro-emetic
Apomorphine
Pro-emetic
