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Kaplan Step 1 > GI Pharm > Flashcards

GI Pharm Flashcards

1
Q

Cimetidine

A

Histamine (H2) antagonist on gastric parietal cells

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2
Q

Ranitidine

A

Histamine (H2) antagonist on gastric parietal cells

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3
Q

Omeprazole

A

Gastric proton pump inhibitor. Inhibits H+/K+ ATPase on gastric parietal cells

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4
Q

Pirenzipine (ADD MORE)

A

M1 antagonist

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5
Q

Bismuth Salicylate

A

Peptobismol. Good for H. Pylori. Creates a clay that covers ulcers. Good anti-diarrheal

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6
Q

Loperamide

A

Mu-opiod AGONIST on enteric neurons. Opioid activation decreases Ach release

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7
Q

Diphenoxylate

A

Mu-opiod AGONIST on enteric neurons. Opioid activation decreases Ach release

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8
Q

Clonidine

A

Alpha-2 AGONIST on enterics. Alpha 2 agonism decreases Ach release

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9
Q

Alosetron

A

5HT3 ANTAGONIST. Serotonin receptors promote peristalsis

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10
Q

Octreotide

A

Somatostatin mimetic. Acts to decreases other gastric secretions. Slows down motility in high doses

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11
Q

Bethanechol

A

M3 agonist. Promotes gut motility

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12
Q

Neostigmine

A

Ach esterase inhibitor. Inhibits the enzyme that breaks down Ach and increases Ach presence

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13
Q

Metochlopramide

A

D2 ANTAGONIST (with 5HT4 agonism functions). Dopamine limits Ach function, so by inhibiting it, you increase Ach activity. Also inhibits D2 on CTZ - functions as anti-emesis

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14
Q

Domperidone

A

D2 ANTAGONIST. Dopamine limits Ach function, so by inhibiting it, you increase Ach activity.

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15
Q

Prucalopride

A

5HT4 agonist. Promotes gut motility

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16
Q

Odansetron

A

5HT3 ANTAGONIST. Anti-emetic (especially for chemo induced vomiting which tends to activate serotonin)

17
Q

Chlorpromazine

A

D2 antagonist on emetic pathway. Anti-emetic.

18
Q

Scopolamine

A

Muscarinic antagonist. Transdermal patch near the ear. Good for motion sickness

19
Q

Promethazine

A

H1 antagonist in the histamine receptor on cerebellum. Sends its neurons to vomiting center. Anti-emetic

20
Q

D9-THC

A

Cannabinoid agonist. Prevents NT release on neurons traveling to vomiting center

21
Q

Aprepitant

A

NK1 antagonist. Blocks NK1 receptor on chemoreceptor trigger zone (CTZ) and solitary nucleus on the path to vomiting center

22
Q

Ipecac

A

Pro-emetic

23
Q

Apomorphine

A

Pro-emetic

Kaplan Step 1 (8 decks)

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