GI Pathology Flashcards
The histologic diagnosis of Barrett’s esophagus is based on
A. Replacement of squamous mucosa by glandular mucosa
B. Glandular hyperplasia with active inflammation
C. Intestinal goblet cells in the glandular mucosa
D. Presence of glandular dysplasia
C
The most common primary neoplasm of the appendix is A. Mucinous cystadenoma B. Carcinoid C. Mucoceole D. Lymphoma
B
Meckel’s diverticulum may cause/be A. Peptic ulcer disease of the ileum B. Intussuception C. Asymptomatic D. AOTA
D
In the western world, the most common cause of cirrhosis is A. Alcoholic liver disease B. Viral hepatitis C. Biliary disease D. Alpha-1 antitrypsin deficiency
A
In the Philippines, B is the most common followed by A. Other causes are primary
hemochromatosis and Wilson’s disease.
The clinical course of Rotor syndrome (complete name Rotor-Manahan-Florentin syndrome)
is
A. Demise during childhood
B. Demise in early adulthood
C. Intermittent episodes of hepatic failure
D. Innocuous
D
In chronic hepatitis, the hallmark of irreversible liver damage is
A. Hepatocyte necrosis involving 70% of liver mass
B. The deposition of fibrous tissue
C. Predominantly conjugated hyperbilirubinemia
D. Predominantly unconjugated hyperbilirubinemia
B
Mallory bodies may be seen in A. Alcoholic liver disease B. Wilson’s disease C. Hepatocytes with denaturated cytokeratin intermediate filament D. AOTA
D
The so-called “bile duct proliferation” in the liver is
A. A pre-neoplastic phenomenon
B. A direct effect of cirrhosis
C. The biliary system’s attempt at reducing increased intraductal bile pressure
D. An histologic evidence of unconjugated hyperbilirubinemia
C
This occurs when the bile duct is obstructed for whatever reason, causing bile to accumulate in it.
The duct then becomes tortuous, resulting in seemingly multiple ducts upon cross-section
A histologic differential diagnosis of cholangiocarcinoma
A. Klatskin tumor
B. Metastatic pancreatic duct CA to the liver
C. Hepatic adenoma
D. Metastatic alveolar cells CA of the pancreas
B
The more common type of gallbladder stone in Asia is A. Predominantly cholesterol B. Predominantly pigment C. Predominantly fat D. All occur in equal frequency
B
Most common primary site of carcinoid tumor A. Esophageal stomach B. Small intestine C. Appendix D. Colon and rectum
C
The etiopathogenesis behind classic pancreatitis is
A. Oversecretion of pancreatic enzymes
B. Premature activation of pancreatic enzymes
C. Obstruction of pancreatic duct
D. Underdigestion due to undersecretion of pancreatic enzymes
B
Most common location of squamous cell CA of the esophagus A. Proximal third B. Middle third C. Distal third D. Equal distribution
B
The definitive liver biopsy feature of extrahepatic biliary atresia is
A. Bile duct proliferation
B. Bile duct destruction
C. Parenchymal hepatocellular cholestasis
D. Portal tract edema and fibrosis
A
True of Gastrointestinal Stromal Tumor (GIST) EXCEPT
A. Arises from the Cajal cell
B. Typically an intramural tumor
C. Is CD 117 positive all the time
D. CD 117 positive tumors will usually respond to therapy (“Gleevec”)
C?
The histologic basis for the diagnosis of acute appendicitis is
A. Considerable neutrophils in the mucosa
B. Considerably neutrophils in the muscularis propria
C. Luminal distension
D. Considerable serosal neutrophils
B
About Crohn’s disease (CD) and ulcerative colitis (UC), which is true?
A. Both CD and UC feature characteristic transmural inflammation
B. Both CD and UC have malignant potential
C. Both CD and UC develop fistulas/sinuses
D. Both CD and UC feature characteristic skip lesions
B
Disease associated with H. pylori infection EXCEPT A. Stress gastritis B. Peptic ulcer disease C. Gastric carcinoma D. Lymphoma
A
The most common cause of esophageal varices in the Philippines
A. Alcoholic cirrhosis
B. Hepatic schistosomiasis
C. Hepatocellular carcinoma
D. Diffuse fibrosing granulomatous disease of the liver
B
Hepatic failure in cirrhosis
A. Deposition of collagen in the space of Disse
B. Reorganization (“short-circuiting”) of the vascular microarchitecture of the liver
C. Loss of hepatocyte mass
D. AOTA
D
Which of the following is not a “popular” causative pathway of acute pancreatitis?
A. Defective pancreatic acinar intracellular transport
B. Pancreatic acinar cell injury
C. Pancreatic duct obstruction
D. Native molecular hyperactivity of pancreatic enzyme
D
Pancreatic carcinomas of the head usually offer a better “outcome” than carcinomas of the
body or tail because
A. Head carcinomas are inherently less aggressive
B. Body and tail carcinomas grow faster and metastasize earlier
C. Head carcinomas obstruct earlier and are therefore discovered earlier
D. Body and tail carcinomas invade the lymphatics earlier
C
The more aggressive ductal carcinoma of the pancreas arises from the A. Head B. Body C. Tail D. All are equally aggressive
D
The histologic feature(s) of chronic cholecystitis with cholecystolithiasis A. Lymphocyte infiltration in the wall B. Fibrosis C. Muscularis wall thickening D. AOTA
D
