GI inc liver Flashcards
what is acute cholangitis?
infection of the biliary tree caused by biliary outflow obstruction
how does acute cholangitis present?
RUQ pain
fever
jaundice
what is biliary colic?
RUQ pain caused by impacted gallstone at the neck of the gallbladder
what is the trigger for biliary colic?
consumption of fatty foods
how does biliary colic present?
RUQ pain
no fever no jaundice
how does cholecystitis present?
RUQ pain
fever
no jaundice
what is the pathophysiology of acute pancreatitis?
inflammation caused by hypersecretion or back flow of exocrine enzymes which result in auto digestion of the pancreas
what are the causes of pancreatitis?
I - idiopathic
G - gallstones
E - ethanol
T - trauma
S - steroids
M - malignancy / mumps
A - autoimmumne disease
S - scorpion sting
H - hypercalcaemia
E - ERCP
D - drugs
how does acute pancreatitis present?
epigastric pain that radiates to back, is worse after meals and is better leaning forward
nausea and vomiting
decreased appetite
what is the diagnostic criteria for acute pancreatitis?
2 of 3 of:
abdo pain and history suggestive of acute pancreatitis
serum amylase / lipase over 3x the upper lim of normal
imaging findings suggestive
what are the 2 most common causes of acute pancreatitis?
gallstones and alcohol
what is the management of gallstone pancreatitis?
ERCP
cholecystectomy on all pts in the same hospital admission
what is the management of alcohol induced pancreatitis?
benzos for withdrawal
thiamine, folate and B12
how does the pain in appendicitis migrate?
initially it produces umbilical pain
as it progresses it produces localised pain in the right iliac fossa
what is Murphys triad in appendicitis?
low grade fever
nausea and vomiting
right iliac fossa pain
what is the first line imaging in appendicitis?
ultrasound
what is the management of appendicitis?
appendectomy
what is cholecystitis?
inflammation of the gallbladder usually secondary to gallstones
what is the most common type of colorectal cancer?
adenocarcinoma
what do most colorectal cancers arise from?
pre cancerous polyps
what is reccomended for pts who have red flag symptoms for colorectal cancer?
faecal immunoglobulin testing (FIT)
what happens if the FIT is positive?
the pt should be referred on an urgent suspected cancer pathway (2 wk wait)
what is the gold standard diagnostic test for colorectal cancer?
colonoscopy
almost all coeliac pts are positive for what?
HLA DQ2
which antibody is diagnostic of coeliac if strongly positive?
anti tTG
how often do pts w/ coeliac disease need the pneumococcal vaccine?
every 5 yrs
what are diverticula?
mucosal out-pouches in the colonic musculature
what its diverticulosis?
the presence of diverticula w/out symptoms
what antibiotic is most commonly used for the treatment of a diverticulitis flare?
co amoxiclav
what is the management of a pt w/ dysphagia (difficulty swallowing)?
urgent 2 wk referral for endoscopy
how long do you need to stop a PPI before a h. pylori test?
2 wks
what is Barretts oesophagus?
when the lower oesophageal epithelium changes from squamous to columnar epithelium (metaplasia) due to chronic acid reflux
what is the risk of Barretts oesophagus?
it is a pre malignant condition and a significant risk factor for developing oesophageal adenocarcinoma
what is Zollinger-Ellison syndrome?
a rare condition where a duodenal or pancreatic tumour secretes excess quantities of gastrin (hormone that stimulates acid secretion)
what is the likely diagnosis when there is a metabolic acidosis and hypokalaemia?
prolonged vomiting
what is involved in a trans jugular intrahepatic portosystemic shunt (TIPS)?
connecting the hepatic vein into the portal vein
what is the management of pharyngeal pouch?
surgical repar
how does a pharyngeal pouch present?
dysphagia
halitosis
regurgitation
coeliac disease increases the risk of developing which cancer?
T cell lymphoma
a recurrent episode of c diff w/in 12 wks of symptom resolution should be treated w/ what?
fidaxomicin
what is the first line treatment for c diff?
10 days of vancomycin
what is the likely diagnosis of a pt w/ T2DM and abnormal LFTs?
non alcoholic fatty liver disease
what does positive anti-HBc IgG indicate?
chronic hepatitis B
think C and G are kinda similar
what does positive anti-HBc indicate?
acute hepatitis B infection
think A and B are close together in alphabet
which medications are a risk factor for c dif?
PPIs
what is the investigation of choice for a suspected pharyngeal pouch?
barium swallow w/ fluoroscopy
what is primary biliary cholangitis?
a chronic liver disorder commonly seen in females - thought to be autoimmune
what is the M rule for primary biliary cholangitis?
IgM - raised serum IgM
anti Mitochondrial antibodies, M2 subtype
Middle aged women
what its life threatening c dif treated w/?
oral vancomycin and IV metronidazole
what is GORD caused by?
stomach acid flowing through the lower oesophageal sphincter and into the oesophagus
what is a hiatus hernia?
when the stomach herniates up through the diaphragm
what are the 3 key complications of hernias?
incarcerations
obstruction
strangulation
what is incarceration (hernia complication)?
when the hernia cannot be reduced back into its proper place
what is obstruction (hernia complication)?
when the hernia causes an obstruction in the passage of faeces through the bowel
what is strangulation (hernia complication)?
when the hernia is non reducible and the base of the hernia twists cutting off the blood supply
what is an indirect inguinal hernia?
when the bowel herniates through the inguinal canal
where does the inguinal canal run between?
the deep inguinal ring and the superficial inguinal ring
what does a direct inguinal hernia occur due to?
a weakness in hesselbachs triangle
how can you differentiate a direct inguinal hernia from an indirect inguinal hernia?
when pressure is applied over the deep inguinal ring an indirect hernia will remain reduced whereas it will not stop herniation for a direct inguinal hernia
what is a femoral hernia?
when there is herniation of abdominal contents through the femoral canal
what is a sliding hiatus hernia?
when the stomach slides up through the diaphragm w/ the gastro-oesophageal junction passing up into the thorax
what is a rolling hiatus hernia?
when a separate part of the stomach folds around and enters through the diaphragm opening along w/ the oesophagus
what is autoimmune hepatitis?
a rare cause of chronic hepatitis (inflammation in the liver)
who does type 1 autoimmune hepatitis usually affect?
women in their 40s-50s
what is a hepatitis picture on bloods?
raised ALT and AST
no change to ALP
what immunoglobulin is raised in autoimmune hepatitis?
IgG
what are the liver biopsy findings of autoimmune hepatitis?
interface hepatitis
plasma cell infiltration
what is the management of autoimmune hepatitis?
high dose steroids (prednisolone)
immunosuppressants (azothioprine)
what is the most common viral hepatitis in the world?
hepatitis A
how is hepatitis A diagnosed?
IgM antibodies
what is the management of hepatitis A?
usually self limiting
how is hepatitis A transmitted?
faecal oral route
usually through contaminated foods
what type of virus is hepatitis A?
RNA
what type of virus is hepatitis B?
double stranded DNA
how is hepatitis B transmitted?
through blood or bodily fluids
mother to baby (vertical transmission)
what does HBsAg indicate in hepatitis B?
active infection
what does HBeAg indicate in hepatitis B?
high infectivity
what does HBcAb indicate in hepatitis B?
current or past infection
what does HBsAb indicate?
vaccination, past or current infection
what is HBV DNA in hepatitis B?
a direct count of the viral load
what type of virus is hepatitis C?
an RNA virus
how is hepatitis C transmitted?
blood and bodily fluids
what is the management of hepatitis C?
it is curable w/ direct acting antiviral medications
what is the duration of treatment for hepatitis C?
8-12 wks
what type of virus is hepatitis D?
RNA virus
hepatitis D pts can only survive in pts w/ what?
hepatitis B
what is the impact of hepatitis D on hepatitis B?
increases the severity and complications of hepatitis B
what type of virus is hepatitis E?
RNA virus
how is hepatitis E transmitted?
faecal oral route
what is the management of hepatitis E?
nothing it is usually self limiting
what are haemorrhoids?
enlarged anal vascular cushions
what are haemorrhoids assoc w/?
constipation / straining
increased abdo pressure from weight lifting and coughing
pregnancy
obesity
increased age
what are the anal cushions?
specialised submucosal tissue that contain connections between the arteries and the veins
what is a first degree haemorrhoid?
no prolapse
what is a second degree haemorrhoid?
prolapse on straining and return inside the anus when relaxing
what is a third degree haemorrhoid?
prolapses on straining and does not return on relaxing but can be pushed back inside
what is a fourth degree haemorrhoid?
permanently prolapsed
how do haemorrhoids present?
fresh bright red blood on wiping that is not mixed in w/ the stool
what are the features of Crohns disease?
N - no blood or mucus
E - entire GI tract affected (mouth to anus)
S - skip lesions on endoscopy
T - terminal ilium most affected and transmural thickness
S - smoking is a risk factor (don’t set the nest on fire)
what are the features of ulcerative colitis?
C - continuous inflammation
L - limited to the colon and rectum
O - only superficial mucosa affected
S - smoking may be protective
E - excrete blood and mucus
U - use aminosalicylates
P - primary sclerosising cholangitis
what is the initial test for inflammatory bowel disease?
faecal calceprotein
what is the investigation of choice for inflammatory bowel disease?
colonoscopy w/ multiple intestinal biopsies
explain the management of mild to moderate ulcerative colitis?
aminosalicylate (e.g. mesalazine) first line
corticosteroids (e.g. prednisolone) second line
what is the management of severe ulcerative colitis?
iv steroids