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PHRM > GI Drugs > Flashcards

GI Drugs Flashcards

1
Q

MOA of Antacids

A

Neutralize stomach acid by reacting with protons in the lumen of the gut

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2
Q

Magnesium hydroxide causes _____ while Aluminum hydroxide causes _______

A 
Magnesium = MAGtatae = Diarrhea
Aluminum = Ayaw LUMabas = Constipation
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3
Q

Cimetidine has modest effect on meal-stimulated secretion but highly effective in _____ acid secretion

A

Nocturnal

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4
Q

Name 3 mucosal protective agents

A

Sucralfate, Misoprostol, Bismuth

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5
Q

Quadruple therapy in H. pylori infection

A

Omeprazole, Bismuth, Metronidazole, Tetracycline

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6
Q

SE of Bismuth

A

Black stools, darkening of tongue, Encephalopathy

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7
Q

Prokinetic antimicrobial

What is the MOA?

A

Erythromycin

Activates motilin receptors

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8
Q

MOA of Metoclopramide and Domperidone

A

blocks D2 receptors

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9
Q

Drug of Choice for Diabetic Gastroparesis

A

Metoclopramide

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10
Q

Why is domperidone preferred over metoclopramide?

A

Domperidone does not cross the BBB

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11
Q

Triple therapy in H. pylori infection

A

Omeprazole. Ranitidine, Amox or Metronid

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12
Q

MOA of Psyllium

A

Indigestible bulky colloids that absorb water forming a bulky emollient gel that distends colon and promotes peristalsis

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13
Q

MOA of Docusate

A

stool-softening

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14
Q

MOA of lactulose

A

osmotic laxative

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15
Q

MOA of bisacodyl

A

Directly stimulate enteric nervous system

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16
Q

Usual laxative given as preparation for endoscopy

A

Polyethylene glycol

17
Q

SE of Bisacodyl (benign condition)

A

Melanosis coli

18
Q

Example of antidiarrheals

A

Loperamide

Diphenoxylate

19
Q

MOA of antidiarrheals and SE

A

Activates opioid receptors in the enteric nervous system

Paralytic Ileus

20
Q

Paralytic ileus is reversed by

A

Betanechol

21
Q

Used in vomiting (post op and post chemo)

Give MOA

A

Ondansetron

5HT3 receptor antagonist

22
Q

Which 5HT3 antagonist can cause QRS and QT prolongation

A

Dolasetron

23
Q

Drug used in IBD

A

Mesalamine

Balsalazide
Olsalazine
Sulfasalazine

PHRM (14 decks)

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