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PHRM > ✅Anti-TB Drugs > Flashcards

✅Anti-TB Drugs Flashcards

1
Q

Aside from neurotoxicity, what are the notable side effects of isomiazid?

A

Drug induced lupus

Acute hemolysis in G6PD

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2
Q

Most important drug in tuberculosis

A

Isoniazid

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3
Q

Specific vitamin B that treats neuropathy of isoniazid

A

Pyridoxine (B6)

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4
Q

MOA of rifampicin

A

Inhibits DNA dependent RNA polymerase

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5
Q

Other notable side effects of Rifampicin aside from red orange urine

A

Flu like Sx

Hepatotoxicity

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6
Q

MOA of ethambutol

A

Inhibits arabinosyl transferases involved in the synthesis of arabinogalactan in mycobacterial cell wall

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7
Q

What type of colorblindness is ethambutol predisposed to?

A

Red green color blindness

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8
Q

MOA of pyrazinamide

A

Unknown

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9
Q

Other than hepatotoxicity, what is the other notable SE of pyrazinamide?

A

Hyperuricemia

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10
Q

Hepatotoxic anti TB drugs

A

ISO a RED PYRE

Isoniazid

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11
Q

Treatment regimen for category II TB (WHO)

A

Cat 2 - sputum smear pos, relapse, treatment failure, defaulter

2HRZES, 1HRZE, 5HR

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12
Q

Most active drug against M leprae

A

Dapsone

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13
Q

MOA of dapsone

A

Inhibition of folic acid synthesis

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14
Q

Notable side effect of dapsone

A

GI upset
Methemoglobinemia
Acute hemolysis in G6PD

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15
Q

Used in dapsone resistant leprosy

A

Clofazimine

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16
Q

MOA of clofazimine

A

Binds to guanine bases in bacterial DNA

17
Q

Notable SE of clofazimine

A

GI irritation

Skin discoloration

18
Q

Drugs for atypical mycobacteria

A

Prophylaxis:
Azithromycin or clarithromycin With or without Rifabutin

Tx:
Azith or clarith with ethambutol and rifabutin

19
Q

MOA of isoniazid

A

Inhibits mycolic acid synthesis

PHRM (14 decks)

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