GI bacterial pathogens and host response

Question 1

Which factors are bacterial pathogens dependent on

Answer 1

• Nutrients
• Oxygen
• pH
• Host defense factors
• Bile salts - Cholerae needs bile salt to turn on expression of colonization factors

Question 2

What is the pathogenesis of E.coli

Answer 2

Enterotoxigenic E.coli binds to the epithelial cells and deregulates ion channels, that completely opens up –> causing efflux of ions and water –> diarrhea

Question 3

What is the pathogenesis of Cholerae

Answer 3

Vibrio cholerae bacteria cause deregulation of ion channels –> efflux of ions and water –> diarrhea

Cholerae needs bile salt to turn on expression of colonization factors

Question 4

What is often the disease outcome of GI bacterial infection that also can be very lethal

Answer 4

Diarrea, third biggest cause of mortality in children <5 years