Ebstein-Barr virus

Question 1

What symptoms can follow EBV infection

Answer 1

Infectious mononucleosis and granular fever

Question 2

Which cells does EBV infect

Answer 2

Oropharyngeal epithelium and B cells, usually take a latent form

Question 3

Which proteins are expressed in latency 1

Answer 3

Latency = no virions are formed

EBNA-1 is expressed, a viral TF under the control of Qp promoter

Question 4

Which proteins are expressed in latency 2

Answer 4

EBNA-1 and all LMP proteins –> activated NFkB and transmit growth signals also anti-apoptotic

Question 5

Which proteins are expressed in latency 3

Answer 5

All the EBV proteins is expressed, EBNA1-6, LMPs –> The B cell becomes a proliferation machinery and anti-apoptotic

Question 6

How do EBV contribute to cancer development

Answer 6

EBV effectively immortalize B cells and also alter the gene expressions, cause genomic instability, avoid apoptosis etc. however it only causes cancer in immunosuppressant patient since these experience a reactivation