GI 3A- Anatomy of the Liver Flashcards
The sinusoids are lined by _____ endothelium
fenestrated
What is the first pass effect?
Most drugs are absorbed from the GI tract enter the portal circulation and encounter the liver before they are distributed into the general circulation
In which direction is sinusoidal blood flow always directed?
TOWARDS the central vein
tiny ducts called ______ ______ run parallel to the sinusoids and drain bile produced by the hepatocytes
bile canaliculi
Because substances in the plasma move freely into the spaces of Disse, the liver compensates by having an extremely high number of ____ to prevent accumulation of interstitial fluid
lymph flow
What is the area between the hepatocytes and the liver sinusoids where the capillaries are very leaky?
Space of Disse (perisinusoidal space)
If pressure rises in the portal veins and sinusoids so much that fluid leaks through the outer surface of the liver and directly into the abdominal cavity this causes _____
ascites
The lobes of the liver are composed of functional units called___
lobules
Lobules consists of rows upon rows of hepatocytes- ___ flows past hepatocytes via sinusoids from branches of the hepatic portal vein to the central vein of each lobule
blood
What is the order of the hepatobiliary plumbing
- R/L hepatic ducts 2. Common hepatic duct 3. Common bile duct
Within each lobule hepatocytes are arranged into _____ ____ separated by adjacent sinusoids
hepatic cords
What are the 4 lobes of the liver?
- right 2. left 3. quadrate 4. caudate
Do the arterial and venous blood mix in the liver?
Yes
Because of its portal blood supply and extensive lymphatic circulation, the liver is a prime site for _____
metastasis
Hepatic macrophages are called____ cells which remove debris such as bacteria and worn-out blood cells
Kupffer cells
