GFR and clearance Flashcards
What is the goal of renal function?
. The goal of renal function is to maintain the volume
and composition of plasma.
How would you define a medical condition characterized by abnormally high levels of nitrogen-containing compounds (such as urea, creatinine, various body waste compounds, and other nitrogen-rich compounds) in the blood.
Azotemia
Hypertension and hyperglycaemia would be what types of kidney problem?
Pre-renal.
A kidney with intrinsic damage e.g. interstitial
fibrosis has what kind of problem?
.
Renal
Where might Post-renal kidney problems occur?
something happened after the
kidney e.g. urethral blockage, stenosis
Renal damage of the tubules causes problems with what?
Re-absorption and secretion.
Interstitial kidney problems make what hard?
Concentrating urine.
How do NSAIDs work?
NSAIDS are prostaglandins blockers which widen the afferent vessels and reduce glomerulus pressure.
Define GFR?
Glomerular filtration rate (GFR) is the
volume of fluid filtered from the
glomerular capillaries into the Bowman’s
capsule per unit time
What is the GFR of a 25kg dog?
75 mI/mm
What is the GFR of a 500kg horse?
750ml/min
At what % of nephron loss do Cr and BUN indicate renal disease?
70-75%
How does oedema occur in proteinuria?
Reduced efficiency to move fluid from tissues into
blood because less protein in it so oedema forms in tissues.
What determines hydrostatic pressure?
— Cardiac output generates pressure
— Afferent and efferent arterioles determine
relative pressure difference across glomerulus
— Concentration of plasma proteins
What does renal clearance depend on?
Renal clearance depends on glomerular filtration rate (G FR), tubular reabsorption AND tubular secretion.
