Genetics- Bemis

Question 1

What homozygous mutation would lead to immunity from HIV?

Answer 1

Homozygous mutation in CCR5

Question 2

What would a heterozygous CCR5 mutation should in a person infected with HIV?

Answer 2

Slower course of disease

Question 3

Why is resistance common to HIV drugs?

Answer 3

RT is not a very reliable transcriptase- many mistakes!!! Causes a high number of mutations in viral genome

Question 4

What drug would no longer be effective if the HIV virus had tropism for only CXCR4?

Answer 4

Maraviroc - CCR5 antagonist

Question 5

Variable expressivity

Answer 5

Individuals with the same genotype will show variation in phenotype

Question 6

Genetics in Type I Diabetes

Answer 6

HLADR3
HLADR4
They encode the MHC II molecules

Question 7

Genetic association vs. GWAS

Answer 7

Genetic association: one gene or a few genes

GWAS: massive data

Question 8

how can you determine Relative risk for an anorexia nervosa in first degree relatives?

Answer 8

Cohort study

Question 9

What asses frequency of disease and related risk factors at a particular point in time?

Answer 9

Cross-sectional study

Question 10

What kind of study was done in the AN paper Bemis wanted us to read?

Answer 10

GWAS

Question 11

Is AN monogenic or polygenic?

Answer 11

Polygenic

Question 12

Modifier Gene

Answer 12

Results in increased expression of another gene

Question 13

Allelic heterogeneity

Answer 13

Different mutations in the same locus produce the same phenotype