Genetic Testing

Question 1

What are all diseases until proven otherwise?

Answer 1

Genetic

Question 2

What are SSRs

Answer 2

Single sequence repeats. n repetitions of 1-4 base pairs
ex. (A)n, (CA)n, (GAA)n

Question 3

Are SSRs heritable

Answer 3

yes

Question 4

Which are more variable–SSRs or genes

Answer 4

SSRs

Question 5

Can you be 100% sure you’re excluding a parent

Answer 5

Yes

Question 6

Can you 100% sure confirm a parent

Answer 6

No. Can be potential sires you don;t know about, multiple sires allowed by AKC

Question 7

Where do melanoblasts originate

Answer 7

trunk neural crest

Question 8

The E locus is…

Answer 8

yellow/red

Question 9

The B locus is…

Answer 9

Black (B), brown (b)

Question 10

The A locus is…

Answer 10

Agouti. a in dogs, A in cats (tabby)

Question 11

The C locus is…

Answer 11

Full color. c = albino, c^s = temperature sensitive (why siamese have dark colored points)

Question 12

The D locus is…

Answer 12

Full color (D), dilution (d) eg silver labs

Question 13

The M locus is…

Answer 13

Merle (M), m = normal
Merle is not always phenotypically visible and MxM is BAD

Question 14

The S locus is

Answer 14

Spotting. s in dogs, S in cats

Question 15

What is agouti

Answer 15

eumelanin and pheomelanin banded hair
ex tabby in cats
sable, pointed, fawn, brindle, etc in dogs

Question 16

Does ee overcome BB/Bb

Answer 16

Yes. So a B-ee X B-ee will always have yellow offspring

Question 17

Why are most calico cats female

Answer 17

Because O (orange) and O+ (not orange) are both X linked and you need both to be calico

Question 18

Why can you have a calico male

Answer 18

Extra chromosome! XXY

Question 19

Why shouldn’t you cross two merles?

Answer 19

Many problems. Occular & auditory abnormalities, deafness, IOP, microphthalmia, colobomas (defect in iris)