general drugs

Question 1

hemicholinium

Answer 1

blocks uptake of choline

Question 2

vesamicol

Answer 2

blocks uptake of acetylcholine by vesicle

Question 3

boutlinum

Answer 3

blocks release of acetylcholine

Question 4

W-conotoxin

Answer 4

blocks release of acetylcholine

Question 5

presynaptic inhibition of acetylcholine release receptors

Answer 5

stimulation of presynpatic inhibitors receptors: alpha2, D2, M2, opioid, ATP, adenosine, serotonin, neuropeptide Y
in neuromuscular junction: aminoglycosides and tetracyclins.

Question 6

High ca+ in presynaptic Ach neuron

Answer 6

release ach

Question 7

4-aminopyridine

Answer 7

K channel blocks, releases Ach, but not specific for Ach!! . used in MS. not

Question 8

presynpatic stimulatory receptors

Answer 8

M1, AT1, prostaglandins, B2,
in neuromuscular junction: alpha or beta adregenic.
inhibition of inhibitory receptors

Question 9

mecamylamine

Answer 9

inhibits ganglionic receptors of Nicotinic receptors.

used oraly, enters cns; used for smoking cessation.

Question 10

atracurium

Answer 10

blocks neuromuscular junction receptors.

Question 11

name 3 drugs which are competitive ganglionic blocking drugs

Answer 11

hexamethonium, mecmylamine, trimethaphan.

hemamethonium, blocks Nn, taken oraly or parenteraly, used to be used for hypertension.

Question 12

mention non-depolarizing blockers of the ganglions-

Answer 12

nicotine, tetra-ethyl-ammonium (so called TEA)