adregenic drugs

Question 1

metyrosine or methyl-tyrosine

Answer 1

inhibits tyrosine hydroxylase

Question 2

carbidopa

Answer 2

inhibits DOPA decarboxylase

Question 3

FLA63

Answer 3

inhibits dopamine b hydroxylase

Question 4

guanethidine

Answer 4

blocks NE release

Question 5

uptake of catecholamine is blocked by…

Answer 5

imipramine, cocaine or Tricyclic..

other drugs include atomoxetine, reboxetine, duloxetine,

Question 6

drugs which indirectly act as sympathomimetics…

Answer 6

tyramine and amphetamines which cause release of NE from cytoplasmic stores.

Question 7

clorgyline and deprenyl

Answer 7

MAO A / B blockers

Question 8

COMT inhibitor

Answer 8

catechol

Question 9

fenoldopam

Answer 9

is a D1 agonist used in severe hypertension

Question 10

presynaptic stimulation of NE

Answer 10

K blockers, 4-aminopyridine,
high Ca+ extraceullular.
latrotoxin- causes explosive release of NE
activation of B2 receptors (presynaptic)
inhibition of Alpha 2 receptors (yohimbine, mianserin)
activation of presynpatic stimulatory heterorecetpors (AT1 recetpors).
Reuptake inhibitors such as cocaine and antidepressants (amitriptyline)
MAO inhibitors such as tranylcypromine, selegiline and moclobemid,
indirect acting sympathomimetics such as tyramine, ephedrine and amphetamines.

Question 11

prestynaptic inhibition

Answer 11

guanethidine and debrisoquine- blocks release of NE, used in HT.
bretylium- blocker of K channels, IV, used in vent fibrillations.
resepin- blocks uptake by vesicles, brain permeable, causes depletion of serotonin, NA, and dopamine.
Treated for HTN and psycosis(central affect).
methyltyrosine, used for pheo.
and more… (tetradotoxin, saxitoxin( block Na+),
conotoxin
6-oh-dopamine
activation of alpha 2 receptors (presynaptic)- clonidine and methyldopa.