General Anesthetics Flashcards
1
Q
Higher lipid solubility
A
higher potency
2
Q
What is potency influenced by?
A
temp, age, rx
not sex, o2, ph, bp
3
Q
How does cardiac output affect inhalation anesthetics?
A
-increased cardiac output–>slower induction
4
Q
What is FA/FI?
A
End tidal/Inspired
Fa=is the brain partial pressue
5
Q
how do you increase speed of induction
A
increase delivery
6
Q
What are the three main factors that determine uptake into blood?
A
- solubility
- not soluble reaches equilibrium faster and blood compartment is smaller - partial pressure difference
- partial pressure drives movement not concentration - cardiac output
- decreased cardiac output faster
7
Q
Propofol
A
- sedation
- IPSP-GABA?
- decreased CMRO2 and ICP
- dilator
- respiratory depression
8
Q
Ketamine
A
- dissociative anesthesia-short procedures
- NMDA receptor antagonist
- increased CMRO2 and ICP
- *increased BP and heart rate
- *bronchodilator-keep breathing
- bad dreams, salivation, twitchy
9
Q
Ketamine
A
- dissociative anesthesia-short procedures
- NMDA receptor antagonist
- increased CMRO2 and ICP
- *increased BP and heart rate
- *bronchodilator-keep breathing
- bad dreams, salivation, twitchy
10
Q
etomidate
A
- GABA
- decreased CRO2
- constrictor
- *least cardiovascular side effects
- *adrenal supression