General Anesthetics Flashcards

1
Q

Higher lipid solubility

A

higher potency

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2
Q

What is potency influenced by?

A

temp, age, rx

not sex, o2, ph, bp

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3
Q

How does cardiac output affect inhalation anesthetics?

A

-increased cardiac output–>slower induction

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4
Q

What is FA/FI?

A

End tidal/Inspired

Fa=is the brain partial pressue

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5
Q

how do you increase speed of induction

A

increase delivery

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6
Q

What are the three main factors that determine uptake into blood?

A
  1. solubility
    - not soluble reaches equilibrium faster and blood compartment is smaller
  2. partial pressure difference
    - partial pressure drives movement not concentration
  3. cardiac output
    - decreased cardiac output faster
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7
Q

Propofol

A
  • sedation
  • IPSP-GABA?
  • decreased CMRO2 and ICP
  • dilator
  • respiratory depression
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8
Q

Ketamine

A
  • dissociative anesthesia-short procedures
  • NMDA receptor antagonist
  • increased CMRO2 and ICP
  • *increased BP and heart rate
  • *bronchodilator-keep breathing
  • bad dreams, salivation, twitchy
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9
Q

Ketamine

A
  • dissociative anesthesia-short procedures
  • NMDA receptor antagonist
  • increased CMRO2 and ICP
  • *increased BP and heart rate
  • *bronchodilator-keep breathing
  • bad dreams, salivation, twitchy
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10
Q

etomidate

A
  • GABA
  • decreased CRO2
  • constrictor
  • *least cardiovascular side effects
  • *adrenal supression
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