Antibiotics Lecture 30

Question 1

Vancomycin
Mechanism 
Cidal or Static 
Treats
Side Effects
MOR

Answer 1

Cell wall synthesis inhibitor
(D-Ala D-Ala)

Time Dependent
Cidal

1. Gram Positive
2. MRSA
3. C-diff (oral)
   (NO GRAM NEGATIVE)

1. Red man
NOT
1. Nephrotoxicity
2. Ototoxicity
3. Thrombophlebitis 

MOR
1. amino acid modification of Dala Dala –>Dala D lac

Question 2

Dalbavancin
Treats
Side Effects

Answer 2

• more potent and cidal than vanc
  1. VISA/VRE

1. GI
2. Skin reaction

Question 3

Telavancin
Treats
Side Effects

Answer 3

1. Gram Positive
2. MRSA
3. SSSI
4. HAP
5. VAP
6. Higher rate renal toxicity than vanco
7. Teratogenic in animals

Question 4

Oritavancin

Treat

Answer 4

1. MSSA, MRSA, Enterococcus, strep, possible anthrax

Question 5

Oxazolidinones 
Linezolid (PO and IV) 
Mechanism 
Cidal or Static 
Treat
Toxicity
MOR

Answer 5

50S

STATIC

1. Gram Positive
2. MRSA
3. VRE
4. Serotonin Syndrome
5. Bone Marrow Suppression (thrombocytopenia)
6. Peripheral Neuropathy
7. lactic acidosis GI

MOR
1. POint mutation of ribosomal RNA

Question 6

Tedizolid

Difference in Side effects

Answer 6

No SSRI

1. Neuropathy
2. Hematologic
3. NDV

Question 7

Lipopeptide 
Daptomycin 
Mechanism 
Cidal or Static 
Treat 
Side Effects

Answer 7

Binds to membranes–>inhibition of protein, RNA, DNA synthesis

Concentration Dependent
CIDAL

1. VRE, VISA, MRSA
2. NOT PNEUMONIA~~~~~~~~
3. GI
4. Injection site reaction
5. Rash
6. Myopathy

Question 8

Qunupristin-Dalfopristin 
Mechanism 
Cidal or Static 
Treat
Side Effects

Answer 8

Protein synthesis inhibitors
synergistic–>cidal

1. Gram Positive
2. GI intolerance
3. Jaundice
4. Myalgia/Arthralgia