Gene Mutation Flashcards

You may prefer our related Brainscape-certified flashcards:
0
Q

What do mutations form the basis of?

A

Discontinuous variation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Define mutation

A

Any change to the quantity or the structure of the DNA of an organism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Define gene mutation

A

Any change to one or more nucleotide bases, or any rearrangement of the bases in DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Define the substitution of bases

A

Where a nucleotide in a DNA molecule is replaced by another nucleotide that has a different base

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Depending on which new base is substituted for the original base, there are three possible consequences. What are they?

A

A nonsense mutation, mis-sense mutation or a silent mutation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

When does a non-sense mutation occur?

A

If the base change results in the formation of one of the three stop codons that mark the end of a polypeptide chain which means the protein cannot perform its normal function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

When does a mis-sense mutation occur?

A

When the base change results in a different amino acid being coded for so the polypeptide will differ by one amino acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

When does a silent mutation occur?

A

When the substituted base, although different, still codes for the same amino acid as before, so the mutation will have no effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How does a mutation occur by deletion?

A

A nucleotide is lost from the normal DNA sequence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What does a deleted nucleotide create?

A

A frame shift

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are mutagens?

A

Outside factors that increase the mutation rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Give two examples of mutagens

A

High-energy radiation that can disrupt the DNA molecule and chemicals that can alter the DNA structure or interfere with transcription

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

In normal cells, what is the rate of cell division controlled by?

A

Proto-oncogenes which stimulate cell division and tumour suppressor genes that slow cell division

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What can a gene mutation cause proto-oncogenes to mutate into?

A

Oncogenes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How can oncogenes affect cell division?

A

The receptor on the cell surface membrane can be permanently activated so that cell division is switched on even in the absence of growth factors or the oncogene may code for a growth factor that is then produced in excessive amounts, again stimulating excessive cell division

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the two types of tumour?

A

Malignant and Benign