Gene Expression Flashcards
Tryptophan operon is under __________________ in which the molecular signal causes the binding of the ___________ to the ___________
Negative regulation control, repressor, operator
The lactose operon is under _______ control by lactose and _______ control by glucose
Negative, positive
Lactose through allolactose causes __________ of the repressor from operator
Dissociation
High glucose means ______ cAMP and vice versa
Low
Repressor inhibit operon transcription by?
Binding to A-site
Attenuation works as an extra break, _______________ transcription that has escaped repressor mediated inhibition
Inhibiting
When there is not enough amino acid the operon codes for, the ribosome ________, at the sequence coding for leader peptide and __________ is favored, resulting in ___________ _____________ of operon
Stalls, hairpin, complete transcription
DNase hypersensitive sites are regions that are?
Devoid of nucleosomes
Proximal promoter elements are devoted for binding of?
General transcription factors
Distal promoter elements are for?
Gene specific transcription factors
Insulators do what?
Limits range of action of enhancer or repressor sequence
Co-activators have _______ activity while co-depressors have _______ activity
HAT, HDAC
Tamoxifen inhibits gene activation by ___________ through?
Estrogen, inhibition of interaction between estrogen receptor and co-activator
Non-steroid hormones regulate gene expression by?
Intracellular signaling through protein phosphorylation and chromatin remodeling
Activator binding sites are usually seen _________ of RNA polymerase binding sites
Upstream
