Gastric Secretions

Question 1

Secretions in:

cardia

body

pylorus

Answer 1

cardia: 50% gland (mucous)
body: 70% gland (pareital, chief)
pylorus: 40% gland (mucous and enteroendocrine)

Question 2

Gastrin

origin

action

triggers

other

Answer 2

Gastrin

origin: G-cells in antrum
action: parietal cells in body

⇒ increase H⁺ secretion, growth of gastric mucosa, increased gastric motility

triggers: cephalic phase, amomatic aa Trp and Phe
other: increased in Zollinger-Ellison syndrome, increased in chronic PPI use

Question 3

Big 3 parietal cell regulators

Answer 3

gastrin: CCK regulator

ACh: mAChR, vagus + enteric

His: H2 receptor

Question 4

Intrinsic factor

source

mediates

deficiency

Answer 4

Intrinsic factor

source: parietal cells

mediates B12 uptake in ileium

deficiency: autoimmune destruction

pernicious anemia → neural deficits

Question 5

Pepsin

secretion

stimulation

activation

Answer 5

Pepsin

secretion: chief cells
stimulation: ACh, gastrin
activation: H⁺ in environment

Question 6

Mucous gel layer formation

Answer 6

PGE2

secreted mucous and bicarb

increases pH at surface of stomach

NSAIDs and catecholamines suppress

Question 7

Zollinger-Ellison syndrome

Answer 7

gastroma: gastrin-secreting tumor of small intestine or pancreas

hyperplasia/hypertrophy or parietal cells

increased acid secretion

Question 8

Peptic ulcer disease

Answer 8

gastrin increased