Gastric Cancer Flashcards
Adenoma
Cancer that begins in the glandular cells - over 90% of gastric cancers
Lymphoma
Cancer that starts in the immune system
Carcinoid syndrome
Cancer that starts in the hormonal system
Gastrointestinal stromal tumor (GIST)
Rare type of cancer that starts in the nervous system
Gastric carcinoma rank
second leading cause of cancer-related deaths in the world
GC infection
H pylori infection may drive lymphocytes to malignancy
Protective vitamins
Riboflavin and Vitamin B6
Most common treatment for GC
surgery
Risks for Gastric cancer
Advanced age
Chronic atrophic gastritis, pernicious anemia, gastric polyps
Diet high in red meat, salt, preserved foods
Diet low in vitamin E or selenium
Eating foods contaminated with aflatoxin fungus
Ethnicity - young white and Hispanic males, AA from poor socioeconomic backgrounds
Family hx of gastric cancer, Menetrier’s disease, intestinal metaplasia
H pylori infection
Low intake of fruits and vegetables
Smoking
Protective foods
garlic, carotenoids and lycopene, fish, fruits, noherbal tea, cruciferous vegetables, quercetin from apples and yellow onions
Vitamins
Vitamin B6 and riboflavin should be included
Treament with 50 micrograms selenium, 30 miligrams Vitamin E, and 15 miligrams beta-carotene to decrease mortality from gastric cancer
Mitomycin C
Cytotoxic drug - may cause fever, n/v, anorexia, and stomatitis
FU side effects
anorexia, nausea, sore mouth, taste changes, vomiting. Add thiamine. Leucovorin often used with.Gl
imatinib (Gleevec)
useful in GIST, n/v side effects. srinks tumors by more tan half with minimal side effects
Sunitinib (Sutent)
useful in stomach cancer when imatinib isn’t effective
