Colorectal Cancer

Question 1

Colorectal cancer rank

Answer 1

3rd most common type of cancer
2nd leading cause of cancer deaths

Question 2

Ascending colon

Answer 2

Absorbs fluids and salts
Cancer spreads upwards, obstruction is rare

Question 3

Descending colon

Answer 3

Stores feces
Cancer tends to encircle the bowel and cause obstsructions

Question 4

Ileal resection

Answer 4

Vitamin B12 deficiency can occur
Bile salts may be lost in diarrhea
Hyperoxaluria and renal oxalate sontes can be a problem

Question 5

Vitamins

Answer 5

Folic acid, Vitamin B6, Vitamin D, calcium, selenium, omega 3s

Question 6

multidrug combo for metastatic colorectal carcinoma

Answer 6

oxaliplatin, fluorouracil and leucovorin

Question 7

Bevacizumab (Avastin)

Answer 7

leads to significant decrease in colon cancer deaths

Question 8

Cetuximab (Erbitux)

Answer 8

when added to chemo will shrink tumors and delay progression

Question 9

COX-2 inhibitors

Answer 9

may be helpful - 50% of polyps and 85% of colonic tumors in humans overexpress COX-2

Question 10

Diclofenac

Answer 10

preferential COX-2 inhibitor, which can be an effective chemoproventive agent in colon cancer

Question 11

Supplements

Answer 11

Vitamin D3 1100 IU daily seems to be beneficial
Low-dose fish oil may be useful to reduce inflammation
Sea cucumber extract has potential chemopreventive properties
Sour orange has protective liminoid properaties

Question 12

How to prevent future polyps

Answer 12

Hih compliance iwth low-fat high-fiber diet associated with reduced risk of adenoma recurrence
Omit trans-fats as much as possible
High intake of flavonols (beans,onions, apples, tea)