Gas Transport Flashcards
Buffer for O2 in sk muscle
myoglobin
HCO3- controlled by
kidneys
pCO2 controlled by
lungs
Oxygen saturation equation
amount of Hb bound to O2/total Hb with available O2 binding sites
2,3-BPG
H+
pCO2
temperature
affect O2 binding to Hb where
at end organs
3 forms of CO2 in blood
dissloved CO2
HCO3-
carbamino compounds (Hb-bound)
Causes of hypoxia
decreased arterial O2
anemia
blood flow disruption
posin ie cyanide, blocks e- transport chain
Causes of right shift in O2 curve
2,3-BPG
increased temp
low pH
increased pCO2
CO poisining
shift in O2 saturation curve
Forms of O2 in blood
dissolved in plasma
(non-saturateable)
bound to Hb
(saturatable)
Anemia
shift in O2 dissociation curve
downward shift
Most CO2 exists in blood as
bicarb
Right shift in O2 dissociation curve causes
less affinity of Hb for O2
improves O2 delivery to tissues
CO2 on Hb dissociation curve
linear and steep
O2 shifts CO2 Hb dissociation curve
right
