Control of Ventilation Flashcards
1
Q
Most important determinant of RR
A
arterial pCO2
2
Q
How pCO2 is sensed in central control
A
arterial CO2 diffuses into CSF because it’s nonpolar
CA converts to H+ and HCO3-
pre-Bötzinger area of medulla senses
3
Q
Pacemaker resting potential
A
unstable
4
Q
Abominal muscles used in
A
forced expiration
5
Q
Mechanism of peripheral chemoreceptors
responding to CO2
A
increased AMP activates AMPK
AMPK blocks K+ channels
depolarization
Ca2+ enters cell
increased firing
increased RR
6
Q
Which peripheral receptor also responds to pH?
A
carotid body
7
Q
Respond to engorgement of capillaries and increased interstitial pressure
A
J-receptors
juxtacapillary receptors
8
Q
When O2 drives RR
A
COPD
high altitude
