Gas exchange and ventilation Flashcards

1
Q

What happens to upper respiratory tract when inhalation

A

Tends to constrict when air is drawn into the lungs

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2
Q

What happens to lower respiratory tract when inhalation

A

expands when air is drawn into the lungs

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3
Q

Alveolar pressure

A

pressure inside the alveoli relative to atmospheric pressure

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4
Q

Intrapleural pressure

A

pressure between the pleural membranes

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5
Q

transmural pressure

A

Alveolar pressure MINUS intrapleural pressure

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6
Q

What happens in Inhalation

A

Intercostal muscles contract
Ribcage is raised
Diaphragm muscles contracts and flattens
volume of thoracic cavity increases
lungs are pulled open
air is pulled into lungs through trachea

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7
Q

What happens in exhalation

A

intercostal muscles contract
ribcage falls
diaphragm muscles relaxes and domed shape
volume of thoracic cavity decreases
lungs are compressed
expired gas flows out through trachea

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8
Q

What is Lung compliance

A

Measure of stretchiness of the lung

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9
Q

High lung compliance

A

very stretchy so a small amount of pressure results in a large increase in volume (easy to inflate)

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10
Q

Low lung compliance

A

Not very stretchy so a large amount of pressure required to increase in volume (difficult to inflate)

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11
Q

How does Surface tension and alveoli interact

A

watery lining on inner surface of alveoli Water molecules attract to each other in alveoli and gives a pull towards centre of alveolus causing alveoli difficult to inflate

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12
Q

Surfactant interact with alveoli

A

Some alveolar cells produce surfactant that surfactant sit on surface of watery lining so reduces ability for water molecules to attract each other reducing pull towards centre and meaning alveoli are easier to inflate

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13
Q

Tidal volume

A

Volume of air in a normal breath

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14
Q

residual volume

A

volume of air in lungs after maximum forceful expiration

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15
Q

Vital capacity

A

Maximum volume of air can be expelled from lungs after a maximum inhalation

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16
Q

Total lung capacity

A

The volume of air at maximum inflation

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17
Q

Typical total lung volume human 75kg

A

6L

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18
Q

Typical tidal volume human 75kg

A

0.5L

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19
Q

Typical total lung volume mouse 0.035kg

A

0.001L

20
Q

Typical tidal volume mouse 0.035kg

A

0.0005L

21
Q

Typical total lung volume dog 20kg

A

2.2L

22
Q

Typical tidal volume dog 20kg

A

0.25L

23
Q

Typical total lung volume horse 500kg

A

55L

24
Q

Typical tidal volume horse 500kg

A

5L

25
Q

How to find total lung volume from body mass

A

~~~divide by 10

26
Q

How to find tidal volume from body mass

A

~~~divide by 100

27
Q

Factors affecting gas exchange

A

alveolar surface area
thin aveolar barrier
high blood flow
fluid film inside aveoli
regular refilling with fresh air

28
Q

How does alveolar surface area effect diffusion

A

increase rate of diffusion

29
Q

How does alveolar barrier effect diddusion

A

increase rate of diffusion

30
Q

how does high blood flow effect diffusion

A

increase rate of diffusion as low 02/high C02 removed so concentration gradient maintained

31
Q

how does fluid film inside alveoli effect diffusion

A

increase rate of C02 diffusion as can dissolve in fluid

32
Q

How does regular refilling with fresh air effect diffusion

A

increases rate of diffusion by maintaining concentration gradients

33
Q

What part of the brain controls ventilation and how

A

medulla and chemoreceptors detect low P02/ high PC02 or vice versa and either increase or decrease intercostal muscles/diaphragm rate respectively

34
Q

What intercostal muscles for inspiration

A

innner

35
Q

What intercostal muscles for expiration

A

external

36
Q

how to calculate transmural pressure

A

alveolar - intrapleural pressure

37
Q

What happens to the 2 pressures when inspiration

A

alveolar decreases and intrapleural decreases further

38
Q

Describe/draw graph of tidal volume

A

insert image

39
Q

Describe/draw graph of intrapleural pressure

A

insert image

40
Q

Describe/draw graph of airflow

A

insert image

41
Q

Describe/draw graph of alveolar pressure

A

insert image

42
Q

How to calculate Ventilation( L min^-1)

A

Tidal volume(l) x Respiratory rate ( breaths min^-1)

43
Q

What is oxygen consumption

A

Oxygen is used by most cells in body to release energy. The volume of oxygen consumed by an animal per minute reflects metabolic rate and is expressed relative to body weight of animal so comparisons can be made. e.g. racehorses

44
Q

How to calculate volume of OXYGEN consumed

A

Subtract volume exhaled of oxygen from inhaled volume of oxygen

45
Q

How to calculate oxygen consumption/V02 max

A

(frac Conc oxygen inhaled air (FiO2) - frac conc oxygen exhaled air (FeO2) x Ventilation(volume inhaled and exhaled) ) divide by body mass

46
Q

How to calculate V02 max (L min^-1 kg^-1) equation

A

((FiO2 - FeO2) x V)/ body mass