Gametogenesis III (2nd lecture) Flashcards
What is spermatogenesis?
Male gametogenesis
What is the default sex?
Female
How does development occur is there is no Sry?
Female
What is the testis determining factor?
Sry
What is Sry?
A TF that activates Sox9
What is responsible for upregulating anti-Mullerian hormone (AMH)?
Sox9 and steroidogenic factor 1
What does Sry specifically induce?
Sex cords that form seminiferous tubules
What are sex cords?
embryonic structures that develop within the gonads and play a crucial role in the development of reproductive tissues
What do sertoli cells secrete?
Anti-mullerian hormone
Why do Sertoli cells secrete AMH?
To prevent female development
What do leydig cells do?
Secrete testosterone
Why do leydig cells secrete testosterone?
To promote development of the male reproductive system
What does testosterone promote development of?
Mesonephric duct