Morphogenesis (cleavage and gastrulation) in drosophila II Flashcards
Active toll effect on dorsal?
Dorsal goes into the nucleus
Inactive toll effect on dorsal?
Dorsal doesn’t go into the nucleus–> stays in the cytoplasm
What is the TIR intracellular domain of the toll receptor similar to?
IL-1 receptor intracellular domain
Differences in toll’s role depending on the age of the organism?
Embryo–> dorsal ventral patterning
Adult–> response to bacterial infection
What does gastrulation do?
transforms the blastoderm embryo from a one-dimensional layer of epithelial cells into a multidimensional multilayered structure
What is formed as a result of gastrulation?
Tissue layers–> germ layers
Three germ layers?
Endoderm, mesoderm, ectoderm
What does the endoderm give rise to in drosophila?
Intestinal system (midgut)
What does the mesoderm give rise to in drosophila?
muscle, heart, blood
What does the ectoderm give rise to in drosophila?
epidermis (exoskeleton), nervous system
What is germ band extension?
results in the elongation of the three germ layers along the antero-posterior axis of the embryo
What is ventral furrow formation?
Ventral cells invaginate
Result of ventral furrow formation?
Ventral cells invaginating gives rise to the mesoderm
What does posterior midgut invagination lead to?
Posterior midgut, as well as carrying the pole cells inside the embryo
How long does the cephalic furrow and dorsal fold last?
Not v long–> transient structures
What are posterior midgut invagination, ventral furrow formation and convergent extension all reliant on?
Actomyosin cytoskeleton
Role of actomyosin in cel shortening and junctional relocation?
They occur independently of actomyosin
Where are the cells expressing twist and snail in early morphogenesis?
Most ventral
What are twist and snail?
TFs that play a key role in regulating genes that will regulate morphogenesis
Which gap genes are expressed by the most posterior cells of the embryo?
Huckebein and tailless
Role of huckebein and tailless?
Roles in morphogenetic processes involved in posterior midgut formation
What kind of genes are even, skipped and runt?
Pair rule
Role of even, skipped and runt?
Axis elongation process
Where does the ventral furrow start?
Just posterior to the cephalic furrow
