GABA Flashcards
GABA in the Astrocyte
Turns into GLUTAMINE
- By Enzyme GABA-Transaminase
Etomidate Binding site
TRANSMEMBRANE domain
- BETA/ALPHA interfaces
Enzyme used to Convert GABA to GlutAMINE
GABA alpha-Ketoglutarate Transaminases
GABA A Receptor
- Pseudo -symmetric membrane spanning CHLORIDE Ion channel
- 5 homologous subunits with 4 TRANSMEMBRANE regions
Where in the Brain does GABA have its effects?
The AMYGDALA
Ligand sites in the EC GABA Receptor
- GABA
- BENZODIAZEPINE
- Picrotoxin
- Anesthetic (Barbituate)
- Steroid
- Volatile Anesthetic (Halothane)
What is a Direct precursor to GABA?
Glutamate
T/F: Metabolism of GABA is only Catabolic
False
- Catabolic AND Anabolic
What does GABA stand for?
Gamma Amino Butyric Acid
Enzyme necessary for the formation of GABA
GAD
- Glutamic Acid Decarboxylase
GABA binds to which ligand site on the GABA A receptor?
Extracellular ALPHA/BETA Interface
Pathway for the Formation of GABA
- Glutamine (From Astrocyte)
- GLN —> Glutamate (Glu)
- GLU ———> GABA
- with help of Enzyme GAD
Benzodiazepine interface
- Extracellular domain
- ALPHA/GAMMA Interface
Tonic vs Phasic inhibition
Tonic
- Sleep/Wake cycle
Phasic
- Short lasting
Role of GABA
Chief INHIBITORY Neurotransmitter in the CNS in mammals
Glycine Receptor
- Similar to GABA receptor
- INHIBITORY Neurotransmitter
The GABA A receptor is what kind of CHANNEL?
Chloride (Cl-)
Subunits that make up a GABA A Receptor
- 2 Beta-2
- 2 Alpha-1
- 1 Gamma-2
GABA is a ____ that gets packaged into _____ at the _____ neuron.
- Neurotransmitter
- Vesicles
- Pre-synaptic
Each Subunit has what?
4 transmembrane regions
