G-Protein Coupled Receptor Flashcards
what are g-protein coupled receptors?
superfamily of proteins within plasma membrane
what is basic structure of g-protein coupled receptors?
7 transmembrane domains
3 intracelullar loops
3 extracellular loops
n and c terminals
what are units associated with c terminal
alpha
beta
gamma
what are the heterodimeric units
alpha and beta
what is the purpose of alpha subunit
binds GTP or GDp
how are subfamilies of receptors classified?
based on sequences
what is the process of receptor activation of heterotrimeric g proteins?
ligand extracellularly binds conformational change of c terminal alpha, beta, gamma release GTP -> GDP intracellular signalling cascade
what are 4 examples of receptor agonists?
biogenic amines
lipids
amino acids and ions
peptides and proteins
what are GPCRs
major drug targets because associated with many diseases
what are effector proteins?
cause a secondary messenger
what is phosphatidyl inositol 3 kinase?
major pathway leading to growth
what are the products of phospholipase C
diaglycerol (DAG)
inositol 1 4 5 triphosphate (IP3)
protein kinase C
