Willin to Hippo

Question 1

what is the function of merlin and expanded?

Answer 1

adhesion, structure, control activation of hippo

Question 2

what is the role of the hippo pathway?

Answer 2

regulates cell growth, survival, and proliferation : i.e. controls relative organ size control

Question 3

what does a loss of merlin or expanded lead to ?

Answer 3

hyper-proliferation

Question 4

what changes upon phosphorylation of YKI?

Answer 4

unphosphorylated = cell survival and proliferation
phosphorylated = apoptosis

Question 5

what are the mammalian variants of merlin and YKI?

Answer 5

nf2 and YAP

Question 6

what is YAP

Answer 6

an oncoprotein important for organ size homeostasis

closed linked to cancer and is inhibited by the hippo pathway

Question 7

what is tetR

Answer 7

test repressor protein, used to show if willin activates the hippo pathway

Question 8

what does increased willin expression lead to?

Answer 8

activation of hippo components and willin expression leads to decrease of nuclear YAP

Question 9

does willin behave similar to expanded?

Answer 9

similar but different

Question 10

what are MCF10A cells?

Answer 10

breast cancer cell line that show epithelial mesenchymal transitions

Question 11

what is the function of FERM?

Answer 11

activation of the hippo pathway