Focal Therapy Basics

Question 1

What is the % breakdown between multifocal tumors and unifocal tumors

Answer 1

75/25

Question 2

Morbidity risks when patient has multifocal tumors

Answer 2

1. unitary and sexual morbidity

Question 3

what 3 advacements have changed ability to localize and risk stratify prostate cancer

Answer 3

1. Advances in imaging
2. Target BX
3. Genomic testing

Question 4

Patient population addressed by focal therapy

Answer 4

1. Low Risk
2. Favorable/intermediate
3. Salvage therapy

Question 5

Approximatly how many Focal One procedures to date

Answer 5

greater than 50,000

Question 6

Focal therapy represents the valence between A/B

Answer 6

A. Active survailence
B. Overtreament (radical)

Question 7

Focal therapy needs_______to ablate tissue in the designated area

Answer 7

controlled energy

Question 8

What are the two pillars of focal therapy

Answer 8

1. Localization
2. Precision ablation

Question 9

4 key pillars of Focal One system

Answer 9

1. Fully robotic
2. HIFUsion software to fuse MRI/BX
3. Integrated, portable workstation
4. Dynamic focusing

Question 10

Dynamic focusing is

Answer 10

Allows for real time inmaging while delivering treatment and the most advanced HIFU tech to pinpoint target and deliver the energy avoding critical structures

Question 11

Pre-treatement Planning Step 1

Answer 11

1. Load images
2. Edit contour and target areas

Question 12

Pre-treatement planning step 2

Answer 12

Import BX volumes

Question 13

Pre-treatement planning step 3

Answer 13

Real-time ultrasound volume, aquire US volume and edit P contour

Question 14

Pre-treatment planning step 4

Answer 14

MRI/BX/US elastic fusion

Question 15

Pre-treatement planning step 5

Answer 15

Treatment area planning

Question 16

3 goals of planning the treatment area

Answer 16

1. Precise contouring to area
2. visualization of MRI and 3D BX
3. Automatic dispatch of individual lesions

Question 17

Max ablation depth A-P

Answer 17

40mm

Question 18

How many focal points can be targeted in a slice

Answer 18

8

Question 19

This componet has 15 rings, independently power supplied

Answer 19

Spherical Transducer

Question 20

How many independantly power-supplied on a spherical transducer

Answer 20

16

Question 21

How deep is the natural focal point

Answer 21

60mm

Question 22

5 advantages of dynamic focusing

Answer 22

1. Access anterior prostate
2. More homogeneous lesions
3. Faster treatment
4. conformational treatmen to fit lesions/miss criticals
5. Customizable for focal, multi, hemi of full gland

Question 23

Allows ability to pause and modiffy planning on current slice

Answer 23

treatment tracking

Question 24

Tracks the process of the overall treatement with virtual #d Prostate

Answer 24

Treatment Tracking

Question 25

Focal/partial ablation patient type 4

Answer 25

1. Intermediate Risk (G 7)
2. Umnilateral cancer
3. Patients wants to perserve function
4. No need for TURP

Question 26

How long is catheter in place after focal treatement

Answer 26

2-7 with mean of 5

Question 27

Whold gland treatment patient procedure 3

Answer 27

1. Over 70
2. Bilateral disease
3. TURP is perferred, 1 month before or during treatment

Question 28

Whole gland and salvage catheter protocol

Answer 28

2-7 days, 5-7 ideal

Question 29

Patient profile, Salvage 4

Answer 29

1. BX proven recurrance
2. No mets
3. Pas less 4 an no hormon treatment